Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2318601..2319118 Replicon chromosome
Accession NZ_CP062370
Organism Staphylococcus aureus strain NAS_AN_111

Toxin (Protein)


Gene name yoeB Uniprot ID A0A3A3ATA4
Locus tag IF711_RS11315 Protein ID WP_000113265.1
Coordinates 2318852..2319118 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF711_RS11310 Protein ID WP_000584499.1
Coordinates 2318601..2318852 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF711_RS11280 (2314299) 2314299..2315018 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF711_RS11285 (2315015) 2315015..2315746 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF711_RS11290 (2315843) 2315843..2317093 - 1251 WP_001012225.1 FemA/FemB family glycyltransferase FmhA -
IF711_RS11295 (2317348) 2317348..2317710 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF711_RS11300 (2317729) 2317729..2318328 + 600 WP_000162810.1 DsbA family protein -
IF711_RS11305 (2318356) 2318356..2318436 + 81 WP_223197974.1 hypothetical protein -
IF711_RS11310 (2318601) 2318601..2318852 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF711_RS11315 (2318852) 2318852..2319118 + 267 WP_000113265.1 Txe/YoeB family addiction module toxin Toxin
IF711_RS11320 (2319153) 2319153..2319224 + 72 Protein_2200 hypothetical protein -
IF711_RS11325 (2319413) 2319413..2320960 + 1548 WP_000727772.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF711_RS11330 (2321146) 2321146..2321613 + 468 WP_000153347.1 SRPBCC domain-containing protein -
IF711_RS11335 (2321697) 2321697..2321879 + 183 WP_000230292.1 hypothetical protein -
IF711_RS11340 (2322096) 2322096..2322920 + 825 WP_000572038.1 formate/nitrite transporter family protein -
IF711_RS11345 (2323154) 2323154..2323690 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.96 Da        Isoelectric Point: 10.0573

>T174669 WP_000113265.1 NZ_CP062370:2318852-2319118 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174669 NZ_CP081343:c12282-11866 [Pantoea ananatis]
GTGAACAGGACTTATATGCTGGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGCCGCCGTCATTGAGCGGCT
GGAGCAGGCGGTGCTGCGCGGCCACCGCATCGTGGTCTCGGCCATTACTTACTCTGAAATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACGTGCAGCTGGTCGAGGAATTCTGCGCCCGGCTCGATGCCGTCCTGCCCTGGGACCGAGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGTGCTGCGCCTGGCCGGGACGCCGATCGGCCCTAACGACACGGCGATCGC
CGGGCACGCCATCTCCGCGGGCGCCGTGCTGGTAACGAATAATACGCGGGAGTTTGAGCGGGTGCCGGGCCTAGTACTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174669 WP_000584499.1 NZ_CP062370:2318601-2318852 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174669 NZ_CP081343:c12509-12279 [Pantoea ananatis]
ATGAGAACCGTATCTATTTTCAAAAACGGCAATAACCGTGCCATCCGCCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATCGTGCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTTG
AAAAAGCCGATCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGGTTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 7BWF


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References