Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2293576..2293760 Replicon chromosome
Accession NZ_CP062370
Organism Staphylococcus aureus strain NAS_AN_111

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2U0ISP5
Locus tag IF711_RS11180 Protein ID WP_000482652.1
Coordinates 2293576..2293683 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2293700..2293760 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF711_RS11155 2288938..2289411 + 474 WP_000456486.1 GyrI-like domain-containing protein -
IF711_RS11160 2289534..2290745 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
IF711_RS11165 2290927..2291586 - 660 WP_000831298.1 membrane protein -
IF711_RS11170 2291646..2292788 - 1143 WP_001176863.1 glycerate kinase -
IF711_RS11175 2293056..2293442 + 387 WP_000779360.1 flippase GtxA -
IF711_RS11180 2293576..2293683 + 108 WP_000482652.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2293700..2293760 - 61 - - Antitoxin
IF711_RS11185 2294386..2296149 + 1764 WP_240024480.1 ABC transporter ATP-binding protein -
IF711_RS11190 2296174..2297907 + 1734 WP_000486487.1 ABC transporter ATP-binding protein -
IF711_RS11195 2298174..2298305 + 132 WP_223197975.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T174667 WP_000482652.1 NZ_CP062370:2293576-2293683 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T174667 NZ_CP081342:3376241-3376456 [Pantoea ananatis]
ATGAACAAAACCCTAACTAAAACTGATTATTTGATGCGACTGAGGCGCTGTCGCTCTATTGACACGCTGGAACGCGTGAT
TGAAAAAAATAAGTACGAATTATCCGATGAAGAATTAGCAGTATTTTACTCAGCAGCCGATCACCGCCTGGCTGAACTGA
CGATGAACAAGCTCTACGACAAAGTCCCGGTGTCAGTCTGGAAATTTGTACGCTAA

Antitoxin


Download         Length: 61 bp

>AT174667 NZ_CP062370:c2293760-2293700 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2U0ISP5

Antitoxin

Download structure file

References