Detailed information of TA system TA174654

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2582378..2582656
• Replicon: chromosome
• Accession: NZ_CP062368
• Organism: Staphylococcus aureus strain NAS_AN_115

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF712_RS12675
• Protein ID: WP_001802298.1
• Coordinates: 2582378..2582482 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2582478..2582656 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF712_RS12660	2579175..2579957	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
IF712_RS12665	2580025..2580882	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
IF712_RS12670	2581540..2581698	-	159	WP_001792784.1	hypothetical protein	-
IF712_RS12675	2582378..2582482	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2582478..2582656	-	179	-	-	Antitoxin
IF712_RS12685	2582915..2584006	-	1092	WP_240021959.1	transcriptional regulator	-
IF712_RS12690	2584272..2585249	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
IF712_RS12695	2585251..2585571	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF712_RS12700	2585723..2586388	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174654 WP_001802298.1 NZ_CP062368:2582378-2582482 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174654 NZ_CP081314:2450078-2451397 [Citrobacter farmeri]
ATGCCCAAACTCGTAACGTGGATGAATAATCAGCGGGTAGGCGAGTTGACGAAACTGGCCAACGGAGCGCATACATTTAA
GTATGCGTCGGATTGGTTAGCCAACCGATATGCCAGGCCATTGTCGCTTTCGCTGCCACTGCAGGTGGGGAAAATCACGT
CTGATGCCGTGTTTAACTTCTTCGATAACTTGTTGCCTGATAGCCCAATCGTGCGCGACAGGATCGTTAAACGCTATCGC
GCAAAATCAAAGCAACCATTTGATTTATTGTCAGAAGTAGGTCGAGATAGCGTGGGAGCAGTGACATTATTACCGGAAAA
TGAAGCGGTGACAAATCCGGTGATGGTATGGGAAAAGTTAAGTGAGGCAAAGCTTGAAGAGGTGCTGTCGGCTTATAAAT
CAGATATTCCGCTGGGCATGATTAATGAAGAAAATGACTTTCGCATCTCAGTTGCTGGCGCACAGGAAAAGACTGCGCTG
CTCAGAATGGGCAATGACTGGTGTATCCCAAAAGGGATAACGCCAACTACGCATATTATTAAGTTGCCTATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAATATTTTTGTCTACTGCTGGCGAAACAACTCG
GCCTGGATGTTCCTGGAGCCGAAATCATCAAAGCGGGAAGGGTGCGTGCGTTAGCGGTCGAGCGCTTTGACAGACGCTGG
AATGCTGAACGGTCAGTTTTACTCCGCTTGCCGCAGGAAGATATGTGCCAGACATTCGGTTTACCGTCATCAGTCAAATA
CGAATCTGACGGAGGACCTGGCATCGCGCAAATCATGGCGTTTTTGATGGGATCTAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTGTTTCAGTGGTTGATTGGCGCAACGGATGGCCATGCGAAAAACTTCTCTGTTTTTATTCAG
GCCGGCGGCAGTTATCGGCTCACGCCATTTTACGACATTATTTCAGCATTTCCGGTTCTTGGCGGTACGGGAATACACAT
CAGCGATTTGAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAGAAAAACAGCGATCGATAAAATTTATCCGCGTCATT
TTATGGCAACAGCAAAGGCGTTGAAATTTCCGCAAGAGCAGATGCGAGAAATTCTGTGTAAGTTTGCAGAGCAAATACCC
GCAGCGCTGGATAACGTGACTGCCGCATTACCAATAGATTTTCCGGAGAACGTCGCGATGGCAATCAGGAGTAATGTACT
TAGGCTGCATGGTCGGTTAAACCGGGAAACAGAAGAATGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT174654 NZ_CP062368:c2582656-2582478 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin