Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2318409..2318926 | Replicon | chromosome |
| Accession | NZ_CP062368 | ||
| Organism | Staphylococcus aureus strain NAS_AN_115 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A3A3ATA4 |
| Locus tag | IF712_RS11300 | Protein ID | WP_000113265.1 |
| Coordinates | 2318660..2318926 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF712_RS11295 | Protein ID | WP_000584499.1 |
| Coordinates | 2318409..2318660 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF712_RS11265 (2314107) | 2314107..2314826 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
| IF712_RS11270 (2314823) | 2314823..2315554 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| IF712_RS11275 (2315651) | 2315651..2316901 | - | 1251 | WP_001012225.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF712_RS11280 (2317156) | 2317156..2317518 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF712_RS11285 (2317537) | 2317537..2318136 | + | 600 | WP_000162810.1 | DsbA family protein | - |
| IF712_RS11290 (2318164) | 2318164..2318244 | + | 81 | WP_223197974.1 | hypothetical protein | - |
| IF712_RS11295 (2318409) | 2318409..2318660 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF712_RS11300 (2318660) | 2318660..2318926 | + | 267 | WP_000113265.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF712_RS11305 (2318961) | 2318961..2319032 | + | 72 | Protein_2194 | hypothetical protein | - |
| IF712_RS11310 (2319221) | 2319221..2320768 | + | 1548 | WP_000727772.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF712_RS11315 (2320954) | 2320954..2321421 | + | 468 | WP_000153347.1 | SRPBCC domain-containing protein | - |
| IF712_RS11320 (2321505) | 2321505..2321687 | + | 183 | WP_000230292.1 | hypothetical protein | - |
| IF712_RS11325 (2321904) | 2321904..2322728 | + | 825 | WP_000572038.1 | formate/nitrite transporter family protein | - |
| IF712_RS11330 (2322962) | 2322962..2323498 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10436.96 Da Isoelectric Point: 10.0573
>T174652 WP_000113265.1 NZ_CP062368:2318660-2318926 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNNKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174652 NZ_CP081314:1192446-1192814 [Citrobacter farmeri]
ATGAAAACTCGACCTGCTACAATTTCGCGGGCGGCGAAGCCTTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGGGATCAAACCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTTGTAGAAAAGCATGAGTTAGTACGTATCGATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACTGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCACGGCAGTGA
ATGAAAACTCGACCTGCTACAATTTCGCGGGCGGCGAAGCCTTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTTCTTAC
ACGGCTACTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGGGATCAAACCGTTATACAGGAACATATCG
ATGCCGGTATCACTCTGGCTAATGCCGTTAACTTTCTTGTAGAAAAGCATGAGTTAGTACGTATCGATCGCACAGGATTT
ACCTCACAGGAACAAGCGCCATATTTGACTGTGACAGATATCCTTCATGCCAGGAGAGCATGCGGATTAATGAACAGTTG
TTCGTATCGGGAAGTAAGTAATATTGTTCTTAGCCGATCACGGCAGTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174652 WP_000584499.1 NZ_CP062368:2318409-2318660 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174652 NZ_CP081314:1192108-1192425 [Citrobacter farmeri]
ATGAACAACACCACATGGGGCCTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGAT
GCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAATGCCTGAAGTTGGATGTCGCATTCCCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACTACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACTCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAACGCTAA
ATGAACAACACCACATGGGGCCTGCAGCGGGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCGGAT
GCACTATCTGGCTGACCGGGCAAGTATCACCGGTAAGTTTAGTGATGCCGAATGCCTGAAGTTGGATGTCGCATTCCCGC
ATTTTATCAGTCAGATGGAATCAATGCTGACTACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACTCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGTAGTTGCGGCTACGTATATATCGCCATTTATCCCACTCAACGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|