Detailed information of TA system TA174650

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2293384..2293568
• Replicon: chromosome
• Accession: NZ_CP062368
• Organism: Staphylococcus aureus strain NAS_AN_115

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: IF712_RS11165
• Protein ID: WP_000482652.1
• Coordinates: 2293384..2293491 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2293508..2293568 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF712_RS11140	2288746..2289219	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
IF712_RS11145	2289342..2290553	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF712_RS11150	2290735..2291394	-	660	WP_000831298.1	membrane protein	-
IF712_RS11155	2291454..2292596	-	1143	WP_001176863.1	glycerate kinase	-
IF712_RS11160	2292864..2293250	+	387	WP_000779360.1	flippase GtxA	-
IF712_RS11165	2293384..2293491	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2293508..2293568	-	61	-	-	Antitoxin
IF712_RS11170	2294194..2295957	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
IF712_RS11175	2295982..2297715	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
IF712_RS11180	2297982..2298113	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174650 WP_000482652.1 NZ_CP062368:2293384-2293491 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174650 NZ_CP081308:c44957-44577 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
AGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAAATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACTGTAGGCGCTGCGACTGG
CGAGATATCTGTATATTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT174650 NZ_CP062368:c2293568-2293508 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin