Detailed information of TA system TA174642

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 20153..20491
• Replicon: chromosome
• Accession: NZ_CP062368
• Organism: Staphylococcus aureus strain NAS_AN_115

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF712_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 20153..20329 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	20317..20491 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF712_RS00085	17841..17993	+	153	WP_001000058.1	hypothetical protein	-
IF712_RS00090	18039..18326	+	288	WP_001262621.1	hypothetical protein	-
IF712_RS00095	18382..18756	+	375	WP_000340977.1	hypothetical protein	-
IF712_RS00100	19168..19950	+	783	WP_000034846.1	staphylococcal enterotoxin type P	-
IF712_RS00105	20153..20329	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20317..20491	-	175	-	-	Antitoxin
IF712_RS00115	20541..20795	+	255	WP_000611512.1	phage holin	-
IF712_RS00120	20807..21562	+	756	WP_000861026.1	CHAP domain-containing protein	-
IF712_RS00125	21753..22244	+	492	WP_000920042.1	staphylokinase	-
IF712_RS00130	22891..23225	+	335	Protein_26	SH3 domain-containing protein	-
IF712_RS00135	23320..23769	-	450	WP_000727645.1	chemotaxis-inhibiting protein CHIPS	-
IF712_RS00140	24452..24802	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
IF712_RS00145	24855..25115	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	see / sak / chp / scn	1..24802	24801

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174642 WP_011447039.1 NZ_CP062368:20153-20329 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174642 NZ_CP081306:c2847455-2847072 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174642 NZ_CP062368:c20491-20317 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin