Detailed information of TA system TA174636

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2767749..2768012
• Replicon: chromosome
• Accession: NZ_CP062366
• Organism: Staphylococcus aureus strain NAS_AN_123

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF713_RS13925
• Protein ID: WP_001802298.1
• Coordinates: 2767749..2767853 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2767848..2768012 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF713_RS13895	2763133..2763915	+	783	WP_000908176.1	ABC transporter ATP-binding protein	-
IF713_RS13900	2763983..2764840	+	858	WP_000370924.1	HAD family hydrolase	-
IF713_RS13910	2765545..2765637	-	93	WP_001790138.1	hypothetical protein	-
IF713_RS13915	2765926..2767062	+	1137	WP_000115564.1	SAP domain-containing protein	-
IF713_RS13920	2767105..2767588	+	484	Protein_2711	recombinase family protein	-
IF713_RS13925	2767749..2767853	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2767848..2768012	-	165	-	-	Antitoxin
IF713_RS13935	2768353..2769444	-	1092	WP_000495671.1	lytic regulatory protein	-
IF713_RS13940	2769710..2770690	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
IF713_RS13945	2770692..2771012	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF713_RS13950	2771164..2771829	+	666	WP_001024094.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174636 WP_001802298.1 NZ_CP062366:2767749-2767853 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174636 NZ_CP081306:1883820-1884071 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT174636 NZ_CP062366:c2768012-2767848 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin