Detailed information of TA system TA174633

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2476168..2476352
• Replicon: chromosome
• Accession: NZ_CP062366
• Organism: Staphylococcus aureus strain NAS_AN_123

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: IF713_RS12400
• Protein ID: WP_000482650.1
• Coordinates: 2476168..2476275 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2476292..2476352 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF713_RS12375	2471530..2472003	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF713_RS12380	2472126..2473337	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF713_RS12385	2473519..2474178	-	660	WP_000831298.1	membrane protein	-
IF713_RS12390	2474238..2475380	-	1143	WP_001176863.1	glycerate kinase	-
IF713_RS12395	2475648..2476034	+	387	WP_000779358.1	flippase GtxA	-
IF713_RS12400	2476168..2476275	+	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2476292..2476352	-	61	-	-	Antitoxin
IF713_RS12405	2476903..2478666	+	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
IF713_RS12410	2478691..2480424	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF713_RS12415	2480655..2480822	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174633 WP_000482650.1 NZ_CP062366:2476168-2476275 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174633 NZ_CP081306:1045414-1045749 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT174633 NZ_CP062366:c2476352-2476292 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin