Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2444329..2444852 Replicon chromosome
Accession NZ_CP062366
Organism Staphylococcus aureus strain NAS_AN_123

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF713_RS12260 Protein ID WP_000074048.1
Coordinates 2444586..2444852 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF713_RS12255 Protein ID WP_000587616.1
Coordinates 2444329..2444586 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF713_RS12230 (2439409) 2439409..2440602 + 1194 WP_000675401.1 MFS transporter -
IF713_RS12235 (2440826) 2440826..2441575 - 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
IF713_RS12240 (2441770) 2441770..2443347 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
IF713_RS12245 (2443515) 2443515..2443970 - 456 WP_000732082.1 DUF1307 domain-containing protein -
IF713_RS12250 (2444029) 2444029..2444223 + 195 WP_001790145.1 hypothetical protein -
IF713_RS12255 (2444329) 2444329..2444586 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF713_RS12260 (2444586) 2444586..2444852 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF713_RS12265 (2445207) 2445207..2446283 + 1077 WP_001076671.1 M42 family metallopeptidase -
IF713_RS12270 (2446531) 2446531..2447193 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
IF713_RS12275 (2447186) 2447186..2447962 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
IF713_RS12280 (2448358) 2448358..2449545 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174632 WP_000074048.1 NZ_CP062366:2444586-2444852 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174632 NZ_CP081306:903823-904230 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174632 WP_000587616.1 NZ_CP062366:2444329-2444586 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174632 NZ_CP081306:903576-903842 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References