Detailed information of TA system TA174623

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2398844..2399028
• Replicon: chromosome
• Accession: NZ_CP062364
• Organism: Staphylococcus aureus strain NAS_AN_130

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF714_RS11735
• Protein ID: WP_000482647.1
• Coordinates: 2398921..2399028 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2398844..2398904 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF714_RS11715 (IF714_11670)	2394354..2394521	-	168	WP_031845053.1	hypothetical protein	-
IF714_RS11720 (IF714_11675)	2394752..2396485	-	1734	WP_000488493.1	ABC transporter ATP-binding protein	-
IF714_RS11725 (IF714_11680)	2396510..2398273	-	1764	WP_001064822.1	ABC transporter ATP-binding protein	-
IF714_RS11730 (IF714_11685)	2398727..2398894	-	168	WP_000301893.1	hypothetical protein	-
-	2398844..2398904	+	61	-	-	Antitoxin
IF714_RS11735 (IF714_11690)	2398921..2399028	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
IF714_RS11740 (IF714_11695)	2399161..2399547	-	387	WP_000779353.1	flippase GtxA	-
IF714_RS11745 (IF714_11700)	2399815..2400957	+	1143	WP_001176863.1	glycerate kinase	-
IF714_RS11750 (IF714_11705)	2401017..2401676	+	660	WP_000831298.1	membrane protein	-
IF714_RS11755 (IF714_11710)	2401859..2403070	+	1212	WP_001191921.1	multidrug effflux MFS transporter	-
IF714_RS11760 (IF714_11715)	2403193..2403666	-	474	WP_000456483.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174623 WP_000482647.1 NZ_CP062364:c2399028-2398921 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174623 NZ_CP081301:c384920-384570 [Paenibacillus sp. PSB04]
TTGATCGTAAAACGCGGCGACGTTTTTTTTGCGGATCTTTCACCCGTAGTCGGTTCTGAGCAAGGTGGAGTCAGGCCCGT
TCTGATCATTCAGAACGATATCGGCAACCGTTTTAGTCCTACGGTCATCGTGGCGGCCATTACCGCCCAGATTCAAAAGG
CAAAGCTGCCGACCCATGTGGAGATCGATGCGGTTTCGCATGGTTTTGACAGGGATTCGGTCATTTTGCTGGAGCAAATC
CGGACCATTGATAAGCAGAGGCTGACGGACAAAATTACCCACCTGGATGAAGAAACGATGAAAAAGGTGGATGATTCGCT
GCAAATCAGTCTCAGCCTGATCGATTTTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174623 NZ_CP062364:2398844-2398904 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin