Detailed information of TA system TA174622

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2373601..2374118
• Replicon: chromosome
• Accession: NZ_CP062364
• Organism: Staphylococcus aureus strain NAS_AN_130

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: IF714_RS11595
• Protein ID: WP_000113263.1
• Coordinates: 2373601..2373867 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YB60
• Locus tag: IF714_RS11600
• Protein ID: WP_000584499.1
• Coordinates: 2373867..2374118 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF714_RS11565 (IF714_11525)	2368861..2369397	-	537	WP_000185901.1	GNAT family N-acetyltransferase	-
IF714_RS11570 (IF714_11530)	2369810..2370634	-	825	WP_000594633.1	formate/nitrite transporter family protein	-
IF714_RS11575 (IF714_11535)	2370838..2371020	-	183	WP_000079140.1	hypothetical protein	-
IF714_RS11580 (IF714_11540)	2371107..2371574	-	468	WP_000153338.1	SRPBCC domain-containing protein	-
IF714_RS11585 (IF714_11545)	2371760..2373307	-	1548	WP_000727757.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
IF714_RS11590	2373495..2373566	-	72	WP_223200558.1	hypothetical protein	-
IF714_RS11595 (IF714_11550)	2373601..2373867	-	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
IF714_RS11600 (IF714_11555)	2373867..2374118	-	252	WP_000584499.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF714_RS11605 (IF714_11560)	2374291..2374382	-	92	Protein_2237	hypothetical protein	-
IF714_RS11610 (IF714_11565)	2374389..2374988	-	600	WP_000162810.1	DsbA family protein	-
IF714_RS11615 (IF714_11570)	2375007..2375369	-	363	WP_000819839.1	DUF4467 domain-containing protein	-
IF714_RS11620 (IF714_11575)	2375624..2376874	+	1251	WP_001012236.1	FemA/FemB family glycyltransferase FmhA	-
IF714_RS11625 (IF714_11580)	2376971..2377702	-	732	WP_000615464.1	amino acid ABC transporter ATP-binding protein	-
IF714_RS11630 (IF714_11585)	2377699..2378418	-	720	WP_000479576.1	amino acid ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T174622 WP_000113263.1 NZ_CP062364:c2373867-2373601 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T174622 NZ_CP081287:c5611395-5611117 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTAGGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9433.60 Da
• Isoelectric Point: 4.3407

>AT174622 WP_000584499.1 NZ_CP062364:c2374118-2373867 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT174622 NZ_CP081287:c5611105-5610800 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTTGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9

Antitoxin

• AlphaFold DB: T1YB60