Detailed information of TA system TA174612

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2580731..2581009
• Replicon: chromosome
• Accession: NZ_CP062362
• Organism: Staphylococcus aureus strain NAS_AN_152

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF721_RS12675
• Protein ID: WP_001802298.1
• Coordinates: 2580731..2580835 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2580831..2581009 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF721_RS12655	2577528..2578310	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
IF721_RS12660	2578378..2579235	+	858	WP_000370928.1	HAD family hydrolase	-
IF721_RS12665	2579893..2580051	-	159	WP_001792784.1	hypothetical protein	-
IF721_RS12670	2580044..2580214	-	171	WP_001792292.1	transposase	-
IF721_RS12675	2580731..2580835	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2580831..2581009	-	179	-	-	Antitoxin
IF721_RS12685	2581334..2582425	-	1092	WP_000495681.1	hypothetical protein	-
IF721_RS12690	2582691..2583671	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
IF721_RS12695	2583673..2583993	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF721_RS12700	2584145..2584810	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (19-155)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174612 WP_001802298.1 NZ_CP062362:2580731-2580835 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174612 NZ_CP081244:c160897-160379 [Phaeobacter inhibens]
ATGACTGGCGATAGCGTGCCCGCCCAAGCGCCCCTTGTCGTAAACGGATGGTCGATTTATGCGCATCCGCTCTTTCTGGA
CCAGCTCGAAGGGCTGATCGAGGAAGTCGAGGCGCGTAAGGCACGCGATCCAAAGACCTGGCGCAAGAAAAACCCGACGA
AACGGCTGGCCGCCATCTTCAAGCTGGTCACCGAGGCCATACCGGCAGATCCGGGTGCCGCTGCCTTCCGGCAAGGCGGC
ACACTCGGCGATCACCGCAAGCACTGGTTCCGGGCGAAATTCTTCCAGCAGTATCGGTTGTTCTACCGGTTCAACAGCGA
TGCGAAGGTCATCGTGGTGGCCTGGGTGAACGACGACAAGACTCTGCGCGCCTATGGCAGCAAGACGGATGCCTATGCGA
CCTTCAAAGGGATGCTGGACAATGGCAACCCACCTGACAATTTCGACGTGCTTTTGAAAGAAGCTGCGGCGGCGCACGAG
GGGTTCGAAATGTCCCTTGAAGCGGTGCCTGATCGGTAA

Antitoxin

Nucleotide

• Length: 179 bp

>AT174612 NZ_CP062362:c2581009-2580831 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin