Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2322817..2323334 Replicon chromosome
Accession NZ_CP062362
Organism Staphylococcus aureus strain NAS_AN_152

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF721_RS11330 Protein ID WP_000113262.1
Coordinates 2323068..2323334 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF721_RS11325 Protein ID WP_000584499.1
Coordinates 2322817..2323068 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF721_RS11295 (2318516) 2318516..2319235 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF721_RS11300 (2319232) 2319232..2319963 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF721_RS11305 (2320060) 2320060..2321310 - 1251 WP_001012228.1 FemA/FemB family glycyltransferase FmhA -
IF721_RS11310 (2321565) 2321565..2321927 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF721_RS11315 (2321946) 2321946..2322545 + 600 WP_000162803.1 DsbA family protein -
IF721_RS11320 (2322573) 2322573..2322653 + 81 WP_223197974.1 hypothetical protein -
IF721_RS11325 (2322817) 2322817..2323068 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF721_RS11330 (2323068) 2323068..2323334 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF721_RS11335 (2323369) 2323369..2323440 + 72 WP_223200558.1 hypothetical protein -
IF721_RS11340 (2323628) 2323628..2325178 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF721_RS11345 (2325364) 2325364..2325831 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF721_RS11350 (2325918) 2325918..2326100 + 183 WP_000079142.1 hypothetical protein -
IF721_RS11355 (2326317) 2326317..2327141 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF721_RS11360 (2327375) 2327375..2327911 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174610 WP_000113262.1 NZ_CP062362:2323068-2323334 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174610 NZ_CP081204:c45690-45313 [Pseudomonas aeruginosa]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174610 WP_000584499.1 NZ_CP062362:2322817-2323068 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174610 NZ_CP081204:c45332-44997 [Pseudomonas aeruginosa]
ATGCAAAAACGAATCATTGAAGGCGTCGAGGTTCAGCGCAGCTCGGGCAACGTCTTTGCCGACCTTGGACTGCCTGACGC
TGAAAAGCTCAAGATCAAGACCGGCCTGGTGGTCGAGATCAGGAGGGCCATGCGCGCCCTTGGGCTGACTCAACAAGCGG
CGGCCAAACGCATGGGCATCCCGCAACCGAAGGTGTCGGGCATGATGCGCGGCGACTTCACCAATCTATCCGAACGCAAG
CTGATGGATTGTCTGAATCGCCTCGGCTACGACATCGAAATCAAGGTACGGCCAGCAGCCGAGCCGATCGGGCATCTAAC
GCTCGCAACCGCTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References