Detailed information of TA system TA174607

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2266258..2266781
• Replicon: chromosome
• Accession: NZ_CP062362
• Organism: Staphylococcus aureus strain NAS_AN_152

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: IF721_RS11055
• Protein ID: WP_000074043.1
• Coordinates: 2266515..2266781 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: IF721_RS11050
• Protein ID: WP_000587618.1
• Coordinates: 2266258..2266515 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF721_RS11035 (2262754)	2262754..2263503	-	750	WP_000072441.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF721_RS11040 (2263698)	2263698..2265275	+	1578	WP_240024421.1	FMN-binding glutamate synthase family protein	-
IF721_RS11045 (2265443)	2265443..2265898	-	456	WP_000732082.1	DUF1307 domain-containing protein	-
IF721_RS11050 (2266258)	2266258..2266515	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF721_RS11055 (2266515)	2266515..2266781	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
IF721_RS11060 (2267137)	2267137..2268213	+	1077	WP_001076665.1	M42 family metallopeptidase	-
IF721_RS11065 (2268462)	2268462..2269124	+	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
IF721_RS11070 (2269117)	2269117..2269893	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
IF721_RS11075 (2270289)	2270289..2271476	+	1188	WP_000026187.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T174607 WP_000074043.1 NZ_CP062362:2266515-2266781 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174607 NZ_CP081202:6908558-6908848 [Pseudomonas aeruginosa]
ATGACCGAGCAAATTTATGATTATGACCCCGCGCAAGCGCTGGACAGCCCGGAGGCCATGGCTCTGTTCATCGCAGACGC
TTTGGATACTGGAGACACCGCCTATATCGCTAAGGCTATGGGAGTCGTGGCCCGCGCCAAGGGGATGACGGAGTTGGCCA
AGGAAACGGGTTTGGCCAGGGAGCAGCTTTACAAATCGTTTAGTGAGCGCGGGAACCCGACATTGAAAACCATGCTGGCA
GTAATGCGAGCTCTGGGCGTTGATCTGACCGCCCGCCCGCATGCTCAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT174607 WP_000587618.1 NZ_CP062362:2266258-2266515 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174607 NZ_CP081202:6908262-6908561 [Pseudomonas aeruginosa]
ATGGTCGAAGTCAAACAAACCGCCACTTTCATGGCATGGGAAAGCAAGCTAAAGGATCGGCGGGCAAAGGCCGTGATCGC
CGCCCGTATCTTCCGATTGGCGAATGGACTACCCGGCGATGTGTCACCAGTCGGCCAGGGTGTGAGCGAGTTGAGGATTC
ACTATGGCCCAGGCTATCGGGTGTACTTCCAGCAGCGCGGGACGGAAATCGTCATCCTGCTATGTGGTGGAGACAAGAGC
AGCCAGGCCAGGGATATAGAAATGGCGAAACGCCTGGCAAATGAGTGGAGGCCGCAATGA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2