Detailed information of TA system TA174603

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 175656..175836
• Replicon: chromosome
• Accession: NZ_CP062362
• Organism: Staphylococcus aureus strain NAS_AN_152

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF721_RS01100
• Protein ID: WP_001801861.1
• Coordinates: 175741..175836 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	175656..175713 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF721_RS01070	172007..173125	+	1119	WP_000072558.1	restriction endonuclease subunit S	-
IF721_RS01075	173773..174189	+	417	WP_020978241.1	DUF1433 domain-containing protein	-
IF721_RS01080	174495..174773	+	279	WP_001798632.1	DUF1433 domain-containing protein	-
IF721_RS01085	174795..175169	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF721_RS01090	175357..175539	+	183	Protein_179	transposase	-
IF721_RS01095	175517..175618	-	102	WP_001791232.1	hypothetical protein	-
-	175656..175713	+	58	-	-	Antitoxin
IF721_RS01100	175741..175836	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF721_RS01105	176287..176733	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF721_RS01110	177418..177801	+	384	WP_000070811.1	hypothetical protein	-
IF721_RS01115	177812..177988	+	177	WP_000375476.1	hypothetical protein	-
IF721_RS01120	178288..178916	+	629	Protein_185	ImmA/IrrE family metallo-endopeptidase	-
IF721_RS01125	179114..179686	-	573	WP_000414206.1	hypothetical protein	-
IF721_RS01130	179787..180128	-	342	WP_000627547.1	DUF3969 family protein	-
IF721_RS01135	180169..180795	-	627	WP_000669021.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	154483..212530	58047

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174603 WP_001801861.1 NZ_CP062362:c175836-175741 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174603 NZ_CP081202:c3514349-3513762 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174603 NZ_CP062362:175656-175713 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin