Detailed information of TA system TA174599

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18832..19170
• Replicon: chromosome
• Accession: NZ_CP062362
• Organism: Staphylococcus aureus strain NAS_AN_152

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF721_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 18832..19008 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	18996..19170 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF721_RS00085	14067..17852	+	3786	WP_000582165.1	phage tail spike protein	-
IF721_RS00090	17842..17994	+	153	WP_001153681.1	hypothetical protein	-
IF721_RS00095	18041..18328	+	288	WP_001040261.1	hypothetical protein	-
IF721_RS00100	18386..18682	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
IF721_RS00105	18832..19008	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	18996..19170	-	175	-	-	Antitoxin
IF721_RS00115	19220..19474	+	255	WP_000611512.1	phage holin	-
IF721_RS00120	19486..20241	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF721_RS00125	20432..20923	+	492	WP_039702443.1	staphylokinase	-
IF721_RS00130	21573..21908	+	336	Protein_25	SH3 domain-containing protein	-
IF721_RS00135	22003..22452	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
IF721_RS00140	23136..23486	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF721_RS00145	23539..23799	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1..23486	23485

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174599 WP_011447039.1 NZ_CP062362:18832-19008 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174599 NZ_CP081202:c1037278-1036523 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGATACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGCGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGGCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174599 NZ_CP062362:c19170-18996 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin