Detailed information of TA system TA174596

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2429122..2429306
• Replicon: chromosome
• Accession: NZ_CP062360
• Organism: Staphylococcus aureus strain NAS_AN_157

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF722_RS12150
• Protein ID: WP_000482647.1
• Coordinates: 2429199..2429306 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2429122..2429182 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF722_RS12135	2424576..2424743	-	168	WP_072491235.1	hypothetical protein	-
IF722_RS12140	2424974..2426707	-	1734	Protein_2348	ABC transporter ATP-binding protein	-
IF722_RS12145	2426732..2428495	-	1764	WP_098818016.1	ABC transporter ATP-binding protein	-
-	2429122..2429182	+	61	-	-	Antitoxin
IF722_RS12150	2429199..2429306	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
IF722_RS12155	2429440..2429826	-	387	WP_000779353.1	flippase GtxA	-
IF722_RS12160	2430094..2431236	+	1143	WP_031906099.1	glycerate kinase	-
IF722_RS12165	2431296..2431955	+	660	WP_000831298.1	membrane protein	-
IF722_RS12170	2432138..2433349	+	1212	WP_001191927.1	multidrug effflux MFS transporter	-
IF722_RS12175	2433472..2433945	-	474	WP_000456493.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174596 WP_000482647.1 NZ_CP062360:c2429306-2429199 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174596 NZ_CP081201:4612174-4612452 [Pseudomonas phytophila]
ATGATTCAGAGTTTTCGCTGCATCGATACCCAGGCACTGTTTGAAACTGGCAAGACCAGACGTTGGAGCGGGTTAAAGAA
TGTAGCAGAACGAAAGCTCGCGATGCTCGATGCCGCAACGGCGCTGAAAGATCTCAAGTCGCCCCCCGGAAATAGACTGG
AGGAGCTTCATGGAGACAGAGAGGGTCAGCACAGCATACGCATCAACGCTCAGTTCAGAGTCTGCTTCTTATGGGGCAGC
AATGGACCGGAACATGTAGAAATTGTTGACTATCACTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174596 NZ_CP062360:2429122-2429182 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin