Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2403755..2404272 | Replicon | chromosome |
| Accession | NZ_CP062360 | ||
| Organism | Staphylococcus aureus strain NAS_AN_157 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | A0A2S6D1N9 |
| Locus tag | IF722_RS12015 | Protein ID | WP_000113263.1 |
| Coordinates | 2403755..2404021 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF722_RS12020 | Protein ID | WP_000584499.1 |
| Coordinates | 2404021..2404272 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF722_RS11990 (2399016) | 2399016..2399552 | - | 537 | WP_098818022.1 | GNAT family N-acetyltransferase | - |
| IF722_RS11995 (2399966) | 2399966..2400790 | - | 825 | WP_072491245.1 | formate/nitrite transporter family protein | - |
| IF722_RS12000 (2400993) | 2400993..2401175 | - | 183 | WP_000079140.1 | hypothetical protein | - |
| IF722_RS12005 (2401262) | 2401262..2401729 | - | 468 | WP_000153340.1 | SRPBCC domain-containing protein | - |
| IF722_RS12010 (2401915) | 2401915..2403462 | - | 1548 | WP_000727756.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF722_RS12015 (2403755) | 2403755..2404021 | - | 267 | WP_000113263.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF722_RS12020 (2404021) | 2404021..2404272 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF722_RS12025 (2404437) | 2404437..2404538 | - | 102 | Protein_2325 | hypothetical protein | - |
| IF722_RS12030 (2404545) | 2404545..2405144 | - | 600 | WP_098818021.1 | DsbA family protein | - |
| IF722_RS12035 (2405163) | 2405163..2405525 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF722_RS12040 (2405780) | 2405780..2407030 | + | 1251 | WP_240025202.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF722_RS12045 (2407127) | 2407127..2407858 | - | 732 | WP_072491244.1 | amino acid ABC transporter ATP-binding protein | - |
| IF722_RS12050 (2407855) | 2407855..2408574 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.01 Da Isoelectric Point: 10.1628
>T174595 WP_000113263.1 NZ_CP062360:c2404021-2403755 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174595 NZ_CP081201:c1911915-1911622 [Pseudomonas phytophila]
GTGACGTACACAATACAGCAGACACAAATATTCACCCATTGGCACGCAGGCTTGCGCGACATACGGGCCAGGATCGCTAT
AGCGCGACGTATTGAGCGCGTATCGGCAGGTAATCTGGGAGACGTGAAAGCCGTCGGCGAAGGAGTGTCCGAGATGCGCG
TAGATGTCGGCGCAGGATACAGAATCTATTTCACCACCCGGGACCGTACGATCATCGTGCTCCTGGTCGGCGGGGATAAA
TCAACTCAGCCGGGTGATATAAGGCAGGCAAAAATAATGGCGAAGGAGGTTTGA
GTGACGTACACAATACAGCAGACACAAATATTCACCCATTGGCACGCAGGCTTGCGCGACATACGGGCCAGGATCGCTAT
AGCGCGACGTATTGAGCGCGTATCGGCAGGTAATCTGGGAGACGTGAAAGCCGTCGGCGAAGGAGTGTCCGAGATGCGCG
TAGATGTCGGCGCAGGATACAGAATCTATTTCACCACCCGGGACCGTACGATCATCGTGCTCCTGGTCGGCGGGGATAAA
TCAACTCAGCCGGGTGATATAAGGCAGGCAAAAATAATGGCGAAGGAGGTTTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174595 WP_000584499.1 NZ_CP062360:c2404272-2404021 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174595 NZ_CP081201:c1911618-1911334 [Pseudomonas phytophila]
ATGTCCACTACCCTAGTGCCGTTTGATATGGCAGCGATCCTTGACAGCGACGAGGCGATCAACGAATACCTCTCCCAGGT
TCTTGCTGATGGTGATACGGACGAACTGATTCGTGCCGTGGGCCATGTAGCAAAAGCACGTGGCATGGCTCAGATAGCCA
AGGATTCAGGACTTGGCAGAGCCAGTCTGTACAAAGCTTTGGCTCCAGGTGCAAAGCCGCGCTTTGACACAGTACTGAAA
GTATTAACTGCACTCGGAATCAAGCTGGTCACTCATCGTCCTTAA
ATGTCCACTACCCTAGTGCCGTTTGATATGGCAGCGATCCTTGACAGCGACGAGGCGATCAACGAATACCTCTCCCAGGT
TCTTGCTGATGGTGATACGGACGAACTGATTCGTGCCGTGGGCCATGTAGCAAAAGCACGTGGCATGGCTCAGATAGCCA
AGGATTCAGGACTTGGCAGAGCCAGTCTGTACAAAGCTTTGGCTCCAGGTGCAAAGCCGCGCTTTGACACAGTACTGAAA
GTATTAACTGCACTCGGAATCAAGCTGGTCACTCATCGTCCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|