Detailed information of TA system TA174589

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 1980908..1981215
• Replicon: chromosome
• Accession: NZ_CP062360
• Organism: Staphylococcus aureus strain NAS_AN_157

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: IF722_RS09740
• Protein ID: WP_072357969.1
• Coordinates: 1981039..1981215 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	1980908..1981047 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF722_RS09700 (1976252)	1976252..1976512	+	261	WP_001791826.1	hypothetical protein	-
IF722_RS09705 (1976565)	1976565..1976915	-	351	WP_000702262.1	complement inhibitor SCIN-A	-
IF722_RS09710 (1977598)	1977598..1978047	+	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
IF722_RS09715 (1978140)	1978140..1978474	-	335	Protein_1875	SH3 domain-containing protein	-
IF722_RS09720 (1979124)	1979124..1979615	-	492	WP_000920041.1	staphylokinase	-
IF722_RS09725 (1979806)	1979806..1980561	-	756	WP_000861038.1	CHAP domain-containing protein	-
IF722_RS09730 (1980573)	1980573..1980827	-	255	WP_000611512.1	phage holin	-
IF722_RS09735 (1980879)	1980879..1980986	+	108	WP_031762631.1	hypothetical protein	-
- (1980908)	1980908..1981047	+	140	NuclAT_0	-	Antitoxin
- (1980908)	1980908..1981047	+	140	NuclAT_0	-	Antitoxin
- (1980908)	1980908..1981047	+	140	NuclAT_0	-	Antitoxin
- (1980908)	1980908..1981047	+	140	NuclAT_0	-	Antitoxin
IF722_RS09740 (1981039)	1981039..1981215	-	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
IF722_RS09745 (1981358)	1981358..1981732	-	375	WP_000340977.1	hypothetical protein	-
IF722_RS09750 (1981788)	1981788..1982075	-	288	WP_001262620.1	hypothetical protein	-
IF722_RS09755 (1982121)	1982121..1982273	-	153	WP_001000058.1	hypothetical protein	-
IF722_RS09760 (1982266)	1982266..1986048	-	3783	WP_124781831.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	1976565..2034068	57503

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T174589 WP_072357969.1 NZ_CP062360:c1981215-1981039 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174589 NZ_CP081200:1795645-1795857 [Pseudomonas sp. 3-2]
GTGCAGAGCAGGTTATTGATCAAGGAGCTGGAGGAGGCAGGCTGGACGCTGGACCGGATAACCGGCAGCCACCACATCTT
CACGCACCGTTACAACCCATACACGATCCCCGTCCCGCATCCGAAAAAGGATTTGCCGGTCGGGACGGTCAAGAGCATCA
GGAGGCGTGCCGGGTTGTACAACCCGCCAGCCAGTTACAGAGGAGATCCGTAA

Antitoxin

Nucleotide

• Length: 140 bp

>AT174589 NZ_CP062360:1980908-1981047 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin