Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2717196..2717610 | Replicon | chromosome |
| Accession | NZ_CP062356 | ||
| Organism | Staphylococcus aureus strain NAS_AN_203 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | IF727_RS13410 | Protein ID | WP_001065046.1 |
| Coordinates | 2717196..2717447 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IF727_RS13415 | Protein ID | WP_000028424.1 |
| Coordinates | 2717437..2717610 (+) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF727_RS13370 (2712853) | 2712853..2713773 | + | 921 | WP_000138475.1 | recombinase RecT | - |
| IF727_RS13375 (2713854) | 2713854..2714471 | + | 618 | WP_072353921.1 | MBL fold metallo-hydrolase | - |
| IF727_RS13380 (2714472) | 2714472..2714942 | + | 471 | WP_000934762.1 | single-stranded DNA-binding protein | - |
| IF727_RS13385 (2714972) | 2714972..2715865 | + | 894 | WP_000148327.1 | DnaD domain-containing protein | - |
| IF727_RS13390 (2715872) | 2715872..2716090 | + | 219 | WP_000338527.1 | hypothetical protein | - |
| IF727_RS13395 (2716099) | 2716099..2716554 | + | 456 | WP_000401965.1 | RusA family crossover junction endodeoxyribonuclease | - |
| IF727_RS13400 (2716567) | 2716567..2716935 | + | 369 | WP_000101270.1 | SA1788 family PVL leukocidin-associated protein | - |
| IF727_RS13405 (2716939) | 2716939..2717181 | + | 243 | WP_000131381.1 | phi PVL orf 51-like protein | - |
| IF727_RS13410 (2717196) | 2717196..2717447 | + | 252 | WP_001065046.1 | DUF1024 family protein | Toxin |
| IF727_RS13415 (2717437) | 2717437..2717610 | + | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| IF727_RS13420 (2717639) | 2717639..2717893 | + | 255 | WP_223297745.1 | hypothetical protein | - |
| IF727_RS13425 (2717894) | 2717894..2718055 | + | 162 | WP_000889682.1 | hypothetical protein | - |
| IF727_RS13430 (2718070) | 2718070..2718603 | + | 534 | WP_001061838.1 | dUTPase | - |
| IF727_RS13435 (2718640) | 2718640..2718885 | + | 246 | WP_001282074.1 | hypothetical protein | - |
| IF727_RS13440 (2718882) | 2718882..2719088 | + | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| IF727_RS13445 (2719085) | 2719085..2719471 | + | 387 | WP_000592201.1 | hypothetical protein | - |
| IF727_RS13450 (2719468) | 2719468..2719617 | + | 150 | WP_000595305.1 | transcriptional activator RinB | - |
| IF727_RS13455 (2719776) | 2719776..2720426 | + | 651 | WP_001005262.1 | hypothetical protein | - |
| IF727_RS13460 (2720426) | 2720426..2720626 | + | 201 | WP_000265041.1 | DUF1514 family protein | - |
| IF727_RS13465 (2720649) | 2720649..2721119 | + | 471 | WP_000282758.1 | hypothetical protein | - |
| IF727_RS13470 (2721234) | 2721234..2721686 | + | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| IF727_RS13475 (2721702) | 2721702..2722046 | + | 345 | WP_000817289.1 | HNH endonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | groEL / hlb | 2694937..2722641 | 27704 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9377.26 Da Isoelectric Point: 3.7128
>T174566 WP_001065046.1 NZ_CP062356:2717196-2717447 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T174566 NZ_CP081192:2122430-2122533 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT174566 WP_000028424.1 NZ_CP062356:2717437-2717610 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT174566 NZ_CP081192:c2122571-2122300 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|