Detailed information of TA system TA174561

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2569207..2569485
• Replicon: chromosome
• Accession: NZ_CP062356
• Organism: Staphylococcus aureus strain NAS_AN_203

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF727_RS12605
• Protein ID: WP_001802298.1
• Coordinates: 2569207..2569311 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2569307..2569485 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF727_RS12590	2566004..2566786	+	783	WP_000908182.1	ABC transporter ATP-binding protein	-
IF727_RS12595	2566854..2567711	+	858	WP_000370925.1	Cof-type HAD-IIB family hydrolase	-
IF727_RS12600	2568369..2568527	-	159	WP_001792784.1	hypothetical protein	-
IF727_RS12605	2569207..2569311	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2569307..2569485	-	179	-	-	Antitoxin
IF727_RS12615	2569744..2570835	-	1092	WP_000495669.1	hypothetical protein	-
IF727_RS12620	2571101..2572078	-	978	WP_000019734.1	CDF family zinc efflux transporter CzrB	-
IF727_RS12625	2572080..2572400	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF727_RS12630	2572552..2573217	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174561 WP_001802298.1 NZ_CP062356:2569207-2569311 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174561 NZ_CP081192:1007185-1007520 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 179 bp

>AT174561 NZ_CP062356:c2569485-2569307 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin