Detailed information of TA system TA174557

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2284175..2284359
• Replicon: chromosome
• Accession: NZ_CP062356
• Organism: Staphylococcus aureus strain NAS_AN_203

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: IF727_RS11115
• Protein ID: WP_000482652.1
• Coordinates: 2284175..2284282 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2284299..2284359 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF727_RS11090	2279537..2280010	+	474	WP_000456486.1	GyrI-like domain-containing protein	-
IF727_RS11095	2280133..2281344	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF727_RS11100	2281526..2282185	-	660	WP_000831298.1	membrane protein	-
IF727_RS11105	2282245..2283387	-	1143	WP_001176863.1	glycerate kinase	-
IF727_RS11110	2283655..2284041	+	387	WP_000779360.1	flippase GtxA	-
IF727_RS11115	2284175..2284282	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2284299..2284359	-	61	-	-	Antitoxin
IF727_RS11120	2284985..2286748	+	1764	WP_001064825.1	ABC transporter ATP-binding protein	-
IF727_RS11125	2286773..2288506	+	1734	WP_000486487.1	ABC transporter ATP-binding protein	-
IF727_RS11130	2288773..2288904	+	132	WP_223197975.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174557 WP_000482652.1 NZ_CP062356:2284175-2284282 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174557 NZ_CP081192:284562-285089 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174557 NZ_CP062356:c2284359-2284299 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin