Detailed information of TA system TA174543

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2582609..2582871
• Replicon: chromosome
• Accession: NZ_CP062354
• Organism: Staphylococcus aureus strain NAS_AN_206

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF730_RS12710
• Protein ID: WP_001802298.1
• Coordinates: 2582609..2582713 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2582708..2582871 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF730_RS12695	2579406..2580188	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
IF730_RS12700	2580256..2581113	+	858	WP_000370928.1	HAD family hydrolase	-
IF730_RS12705	2581771..2581929	-	159	WP_001792784.1	hypothetical protein	-
IF730_RS12710	2582609..2582713	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2582708..2582871	-	164	-	-	Antitoxin
IF730_RS12720	2583155..2584246	-	1092	WP_000495681.1	hypothetical protein	-
IF730_RS12725	2584512..2585492	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
IF730_RS12730	2585494..2585814	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF730_RS12735	2585966..2586631	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174543 WP_001802298.1 NZ_CP062354:2582609-2582713 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174543 NZ_CP081189:870556-870969 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT174543 NZ_CP062354:c2582871-2582708 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin