Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2329283..2329800 Replicon chromosome
Accession NZ_CP062354
Organism Staphylococcus aureus strain NAS_AN_206

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF730_RS11390 Protein ID WP_000113262.1
Coordinates 2329534..2329800 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF730_RS11385 Protein ID WP_000584499.1
Coordinates 2329283..2329534 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF730_RS11355 (2324981) 2324981..2325700 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF730_RS11360 (2325697) 2325697..2326428 + 732 WP_000615470.1 amino acid ABC transporter ATP-binding protein -
IF730_RS11365 (2326525) 2326525..2327775 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
IF730_RS11370 (2328030) 2328030..2328392 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF730_RS11375 (2328411) 2328411..2329010 + 600 WP_000162813.1 DsbA family protein -
IF730_RS11380 (2329017) 2329017..2329118 + 102 WP_001791744.1 hypothetical protein -
IF730_RS11385 (2329283) 2329283..2329534 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF730_RS11390 (2329534) 2329534..2329800 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF730_RS11395 (2329835) 2329835..2329906 + 72 Protein_2214 hypothetical protein -
IF730_RS11400 (2330095) 2330095..2331645 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF730_RS11405 (2331831) 2331831..2332298 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF730_RS11410 (2332382) 2332382..2332564 + 183 WP_000230294.1 hypothetical protein -
IF730_RS11415 (2332781) 2332781..2333605 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF730_RS11420 (2333838) 2333838..2334374 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174542 WP_000113262.1 NZ_CP062354:2329534-2329800 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174542 NZ_CP081189:365064-365339 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174542 WP_000584499.1 NZ_CP062354:2329283-2329534 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174542 NZ_CP081189:364801-365061 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCCCGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References