Detailed information of TA system TA174539

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2273010..2273533
• Replicon: chromosome
• Accession: NZ_CP062354
• Organism: Staphylococcus aureus strain NAS_AN_206

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IF730_RS11125
• Protein ID: WP_000074046.1
• Coordinates: 2273267..2273533 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: IF730_RS11120
• Protein ID: WP_000587615.1
• Coordinates: 2273010..2273267 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF730_RS11100 (2268105)	2268105..2269298	+	1194	WP_000675403.1	MFS transporter	-
IF730_RS11105 (2269522)	2269522..2270271	-	750	WP_000019956.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF730_RS11110 (2270461)	2270461..2272038	+	1578	WP_000143490.1	FMN-binding glutamate synthase family protein	-
IF730_RS11115 (2272188)	2272188..2272652	-	465	WP_000736689.1	DUF1307 domain-containing protein	-
IF730_RS11120 (2273010)	2273010..2273267	+	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF730_RS11125 (2273267)	2273267..2273533	+	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
IF730_RS11130 (2273846)	2273846..2274922	+	1077	WP_001076667.1	M42 family metallopeptidase	-
IF730_RS11135 (2275170)	2275170..2275832	+	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
IF730_RS11140 (2275825)	2275825..2276598	+	774	WP_000072148.1	iron export ABC transporter permease subunit FetB	-
IF730_RS11145 (2276950)	2276950..2278134	+	1185	WP_000115415.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T174539 WP_000074046.1 NZ_CP062354:2273267-2273533 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174539 NZ_CP081187:4777044-4777355 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT174539 WP_000587615.1 NZ_CP062354:2273010-2273267 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174539 NZ_CP081187:4777352-4777798 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2