Detailed information of TA system TA174534

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprA2AS/-
• Location: 20153..20460
• Replicon: chromosome
• Accession: NZ_CP062354
• Organism: Staphylococcus aureus strain NAS_AN_206

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF730_RS00110
• Protein ID: WP_011447039.1
• Coordinates: 20153..20329 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	20319..20460 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF730_RS00090	17841..17993	+	153	WP_001000058.1	hypothetical protein	-
IF730_RS00095	18039..18326	+	288	WP_001262621.1	hypothetical protein	-
IF730_RS00100	18382..18756	+	375	WP_000340977.1	hypothetical protein	-
IF730_RS00105	19168..19950	+	783	WP_000034846.1	staphylococcal enterotoxin type P	-
IF730_RS00110	20153..20329	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	20319..20460	-	142	-	-	Antitoxin
IF730_RS00120	20541..20795	+	255	WP_000611512.1	phage holin	-
IF730_RS00125	20807..21562	+	756	WP_002955266.1	CHAP domain-containing protein	-
IF730_RS00130	21753..22244	+	492	WP_000920042.1	staphylokinase	-
IF730_RS00135	23064..23858	+	795	WP_000238962.1	phosphatidylinositol kinase	-
IF730_RS00140	23865..24602	+	738	WP_000278828.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	see / sak / scn	1..25861	25860

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174534 WP_011447039.1 NZ_CP062354:20153-20329 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174534 NZ_CP081187:3699185-3699460 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Nucleotide

• Length: 142 bp

>AT174534 NZ_CP062354:c20460-20319 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Structures

Toxin

• PDB: 7NS1

Antitoxin