Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2717196..2717610 Replicon chromosome
Accession NZ_CP062352
Organism Staphylococcus aureus strain NAS_AN_233

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IF733_RS13415 Protein ID WP_001065046.1
Coordinates 2717196..2717447 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IF733_RS13420 Protein ID WP_000028424.1
Coordinates 2717437..2717610 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF733_RS13375 (2712853) 2712853..2713773 + 921 WP_000138475.1 recombinase RecT -
IF733_RS13380 (2713854) 2713854..2714471 + 618 WP_072353921.1 MBL fold metallo-hydrolase -
IF733_RS13385 (2714472) 2714472..2714942 + 471 WP_000934762.1 single-stranded DNA-binding protein -
IF733_RS13390 (2714972) 2714972..2715865 + 894 WP_000148327.1 DnaD domain-containing protein -
IF733_RS13395 (2715872) 2715872..2716090 + 219 WP_000338527.1 hypothetical protein -
IF733_RS13400 (2716099) 2716099..2716554 + 456 WP_000401965.1 RusA family crossover junction endodeoxyribonuclease -
IF733_RS13405 (2716567) 2716567..2716935 + 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
IF733_RS13410 (2716939) 2716939..2717181 + 243 WP_000131381.1 phi PVL orf 51-like protein -
IF733_RS13415 (2717196) 2717196..2717447 + 252 WP_001065046.1 DUF1024 family protein Toxin
IF733_RS13420 (2717437) 2717437..2717610 + 174 WP_000028424.1 hypothetical protein Antitoxin
IF733_RS13425 (2717639) 2717639..2717893 + 255 WP_223297745.1 hypothetical protein -
IF733_RS13430 (2717894) 2717894..2718055 + 162 WP_000889682.1 hypothetical protein -
IF733_RS13435 (2718070) 2718070..2718603 + 534 WP_001061838.1 dUTPase -
IF733_RS13440 (2718640) 2718640..2718885 + 246 WP_001282074.1 hypothetical protein -
IF733_RS13445 (2718882) 2718882..2719088 + 207 WP_000195803.1 DUF1381 domain-containing protein -
IF733_RS13450 (2719085) 2719085..2719471 + 387 WP_000592201.1 hypothetical protein -
IF733_RS13455 (2719468) 2719468..2719617 + 150 WP_000595305.1 transcriptional activator RinB -
IF733_RS13460 (2719776) 2719776..2720426 + 651 WP_001005262.1 hypothetical protein -
IF733_RS13465 (2720426) 2720426..2720626 + 201 WP_000265041.1 DUF1514 family protein -
IF733_RS13470 (2720649) 2720649..2721119 + 471 WP_000282758.1 hypothetical protein -
IF733_RS13475 (2721234) 2721234..2721686 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
IF733_RS13480 (2721702) 2721702..2722046 + 345 WP_000817289.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - groEL / hlb 2694937..2722641 27704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T174530 WP_001065046.1 NZ_CP062352:2717196-2717447 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T174530 NZ_CP081187:c1028353-1027826 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT174530 WP_000028424.1 NZ_CP062352:2717437-2717610 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT174530 NZ_CP081187:c1028640-1028350 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References