Detailed information of TA system TA174508

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2577635..2577913
• Replicon: chromosome
• Accession: NZ_CP062350
• Organism: Staphylococcus aureus strain NAS_AN_250

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF736_RS12790
• Protein ID: WP_001802298.1
• Coordinates: 2577635..2577739 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2577735..2577913 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF736_RS12775	2574432..2575214	+	783	WP_000908180.1	ABC transporter ATP-binding protein	-
IF736_RS12780	2575282..2576139	+	858	WP_000370930.1	HAD family hydrolase	-
IF736_RS12785	2576797..2576955	-	159	WP_001792784.1	hypothetical protein	-
IF736_RS12790	2577635..2577739	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2577735..2577913	-	179	-	-	Antitoxin
IF736_RS12800	2578181..2579272	-	1092	WP_000495681.1	hypothetical protein	-
IF736_RS12805	2579538..2580518	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
IF736_RS12810	2580520..2580840	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF736_RS12815	2580992..2581657	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174508 WP_001802298.1 NZ_CP062350:2577635-2577739 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174508 NZ_CP081071:c63499-63212 [Leisingera caerulea]
ATGCCGATCAAGACAACACGTTTCGATGCGGCCGAGTACCTGGATACTATCGAGGCGCAAGCCGAATATCTGGCTGCGGC
TTTCGAAACTGGCGACGAGGCATATATCAAGAACGCTATGGCAACTGTTGCCCGCGCGCGTGGCATGACTGAAATTGCTA
AAGCTGCGGACGTTACGCGGCAGGCGCTTTACAAGGGCTTATCCGAGGCAGGCGATCCGAAGCTCTCAACTGTGCTGGGG
GTGATGAAGGCCCTTGGTATGAAAGTGACAGTTGAGGCGGGGGTTTGA

Antitoxin

Nucleotide

• Length: 179 bp

>AT174508 NZ_CP062350:c2577913-2577735 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin