Detailed information of TA system TA174504

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2292652..2292836
• Replicon: chromosome
• Accession: NZ_CP062350
• Organism: Staphylococcus aureus strain NAS_AN_250

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF736_RS11295
• Protein ID: WP_000482647.1
• Coordinates: 2292652..2292759 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2292776..2292836 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF736_RS11270	2288024..2288497	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF736_RS11275	2288620..2289831	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF736_RS11280	2290013..2290672	-	660	WP_000831298.1	membrane protein	-
IF736_RS11285	2290732..2291874	-	1143	WP_001176863.1	glycerate kinase	-
IF736_RS11290	2292132..2292518	+	387	WP_000779360.1	flippase GtxA	-
IF736_RS11295	2292652..2292759	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2292776..2292836	-	61	-	-	Antitoxin
IF736_RS11300	2293387..2295150	+	1764	WP_106905756.1	ABC transporter ATP-binding protein	-
IF736_RS11305	2295175..2296908	+	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF736_RS11310	2297139..2297306	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174504 WP_000482647.1 NZ_CP062350:2292652-2292759 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174504 NZ_CP081017:3871388-3871546 [Clostridioides difficile]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGAAGAAGATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174504 NZ_CP062350:c2292836-2292776 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin