Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2292652..2292836 Replicon chromosome
Accession NZ_CP062350
Organism Staphylococcus aureus strain NAS_AN_250

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag IF736_RS11295 Protein ID WP_000482647.1
Coordinates 2292652..2292759 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2292776..2292836 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF736_RS11270 2288024..2288497 + 474 WP_000456489.1 GyrI-like domain-containing protein -
IF736_RS11275 2288620..2289831 - 1212 WP_001192075.1 multidrug effflux MFS transporter -
IF736_RS11280 2290013..2290672 - 660 WP_000831298.1 membrane protein -
IF736_RS11285 2290732..2291874 - 1143 WP_001176863.1 glycerate kinase -
IF736_RS11290 2292132..2292518 + 387 WP_000779360.1 flippase GtxA -
IF736_RS11295 2292652..2292759 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2292776..2292836 - 61 - - Antitoxin
IF736_RS11300 2293387..2295150 + 1764 WP_106905756.1 ABC transporter ATP-binding protein -
IF736_RS11305 2295175..2296908 + 1734 WP_000486494.1 ABC transporter ATP-binding protein -
IF736_RS11310 2297139..2297306 + 168 WP_001790576.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T174504 WP_000482647.1 NZ_CP062350:2292652-2292759 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T174504 NZ_CP081017:3871388-3871546 [Clostridioides difficile]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAAAATCGCTTAAATGATAATTTAGAAGAATTGGTTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACGAGTTTGCGAAGAAGATGA

Antitoxin


Download         Length: 61 bp

>AT174504 NZ_CP062350:c2292836-2292776 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References