Detailed information of TA system TA174503

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2260707..2261230
• Replicon: chromosome
• Accession: NZ_CP062350
• Organism: Staphylococcus aureus strain NAS_AN_250

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: T1YCD0
• Locus tag: IF736_RS11155
• Protein ID: WP_000074043.1
• Coordinates: 2260964..2261230 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: IF736_RS11150
• Protein ID: WP_000587618.1
• Coordinates: 2260707..2260964 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF736_RS11130 (2255786)	2255786..2256979	+	1194	WP_000675407.1	MFS transporter	-
IF736_RS11135 (2257203)	2257203..2257952	-	750	WP_000072466.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF736_RS11140 (2258147)	2258147..2259724	+	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
IF736_RS11145 (2259892)	2259892..2260347	-	456	WP_000732076.1	DUF1307 domain-containing protein	-
IF736_RS11150 (2260707)	2260707..2260964	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF736_RS11155 (2260964)	2260964..2261230	+	267	WP_000074043.1	Txe/YoeB family addiction module toxin	Toxin
IF736_RS11160 (2261586)	2261586..2262662	+	1077	WP_001076673.1	M42 family metallopeptidase	-
IF736_RS11165 (2262910)	2262910..2263572	+	663	WP_000923524.1	ATP-binding cassette domain-containing protein	-
IF736_RS11170 (2263565)	2263565..2264341	+	777	WP_000072147.1	iron export ABC transporter permease subunit FetB	-
IF736_RS11175 (2264737)	2264737..2265924	+	1188	WP_000026194.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10657.45 Da
• Isoelectric Point: 10.3584

>T174503 WP_000074043.1 NZ_CP062350:2260964-2261230 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKTFIEIVETLKNNPYKITQSFEKLEPKYLERYSRRINLQHRVVYTIDDRNKVVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174503 NZ_CP081016:c4550604-4550422 [Pseudomonas sp. 2hn]
ATGAAGTACAGCGAGCTACGTCGATGGCTGCGGTCCCAAGGCGCCACCTTCGTTCCTGCCAAAGGCAGCCATTTCAAGGT
TTACCTGGGTGATCGACAAACCATCTTCCCCGATCATGGCGCCAAGGAAATGGGTGAAGGGTTGAGGAAGAAGATCCTCA
AGGATCTTGGGTTACGCGATTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT174503 WP_000587618.1 NZ_CP062350:2260707-2260964 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174503 NZ_CP081016:c4550401-4549976 [Pseudomonas sp. 2hn]
ATGAATTTCGATTATCCGGTGAACGTGCACCGTGATGCAGGCAGTGTCTGGATCAGTTGCCCGGATATCCCCGAGATGGC
CAGTGCGGGGGATACGCTCGATGAGGCGCTGTTCGATGCGGTGGATGCCCTGGAGTCAGCGCTTTCACTGTACGTAGATC
GTCGGGTCGCCATTCCGTTGCCTTCGTCATTGCAATCAGCCGAGGCTGTAGTCAGGTTGCCGGCGTTGACCGCCGCGAAG
GCTGCCTTGTGGAACACCATGATTGCCCAGAACGTAACCAAGACGGAAATGGCCCGACGGCTTGGCGTGAACCGGCCTCA
GGTGGATCGCCTGGTCGATCTGTTGCATCGCTCCAAGATCGAGCAGGTCGAGCATGCCTTGCATGTGTTGGGGCAGCGCA
TCGAACTTGCAGTGGTGGCTGCCTGA

Structures

Toxin

• AlphaFold DB: T1YCD0

Antitoxin

• AlphaFold DB: T1YBB2