Detailed information of TA system TA174496

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18899..19237
• Replicon: chromosome
• Accession: NZ_CP062350
• Organism: Staphylococcus aureus strain NAS_AN_250

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: IF736_RS00105
• Protein ID: WP_072357969.1
• Coordinates: 18899..19075 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19063..19237 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF736_RS00085	14066..17848	+	3783	WP_000582177.1	phage tail spike protein	-
IF736_RS00090	17841..17993	+	153	WP_001000058.1	hypothetical protein	-
IF736_RS00095	18039..18326	+	288	WP_001262620.1	hypothetical protein	-
IF736_RS00100	18382..18756	+	375	WP_000340977.1	hypothetical protein	-
IF736_RS00105	18899..19075	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19063..19237	-	175	-	-	Antitoxin
IF736_RS00115	19287..19541	+	255	WP_000611512.1	phage holin	-
IF736_RS00120	19553..20308	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF736_RS00125	20499..20990	+	492	WP_000920041.1	staphylokinase	-
IF736_RS00130	21641..21975	+	335	Protein_25	SH3 domain-containing protein	-
IF736_RS00135	22068..22517	-	450	WP_000727643.1	chemotaxis-inhibiting protein CHIPS	-
IF736_RS00140	23200..23550	+	351	WP_000702262.1	complement inhibitor SCIN-A	-
IF736_RS00145	23603..23863	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1..23550	23549

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T174496 WP_072357969.1 NZ_CP062350:18899-19075 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174496 NZ_CP081016:446188-446502 [Pseudomonas sp. 2hn]
ATGATTTTCGTCGAGACGTCGATCTTCACTGAGGACTTGCATGAGCTGCTGAGTGATGATGAATACAGGGCTTTCCAGCA
GCATTTGGCTGTGAACCCGACCGCTGGGGATGTGATCCAGCACACTGGCGGGCTTCGCAAGATTCGCTGGGCTGCAAACG
GCAAGGGCAAGCGTGGTGGAGTTCGAGTGATCTACTACTACATCACCGCAGCTGCGCAGATTCGGCTACTGGTGATCTAC
CGGAAGGGCGTGAAAGACGACCTCTCAGAAGACGAGAGGAAAGAGCTGCGCAAACTGAACGAAGGGTGGCAATGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174496 NZ_CP062350:c19237-19063 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACTAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin