Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2884562..2884985 | Replicon | chromosome |
| Accession | NZ_CP062348 | ||
| Organism | Staphylococcus aureus strain NAS_AN_260 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | IF738_RS14415 | Protein ID | WP_086097839.1 |
| Coordinates | 2884562..2884813 (+) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IF738_RS14420 | Protein ID | WP_086097840.1 |
| Coordinates | 2884803..2884985 (+) | Length | 61 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF738_RS14360 (2879890) | 2879890..2880645 | - | 756 | WP_240017877.1 | hypothetical protein | - |
| IF738_RS14365 (2880710) | 2880710..2881480 | + | 771 | WP_001566734.1 | conserved phage C-terminal domain-containing protein | - |
| IF738_RS14370 (2881490) | 2881490..2882269 | + | 780 | WP_001668921.1 | ATP-binding protein | - |
| IF738_RS14375 (2882263) | 2882263..2882424 | + | 162 | WP_000237154.1 | hypothetical protein | - |
| IF738_RS14380 (2882438) | 2882438..2882659 | + | 222 | WP_001123688.1 | DUF3269 family protein | - |
| IF738_RS14385 (2882669) | 2882669..2883073 | + | 405 | WP_217767701.1 | DUF1064 domain-containing protein | - |
| IF738_RS14390 (2883078) | 2883078..2883263 | + | 186 | WP_001187234.1 | DUF3113 family protein | - |
| IF738_RS14395 (2883264) | 2883264..2883623 | + | 360 | WP_106459739.1 | SA1788 family PVL leukocidin-associated protein | - |
| IF738_RS14400 (2883624) | 2883624..2883872 | + | 249 | WP_115282690.1 | SAV1978 family virulence-associated passenger protein | - |
| IF738_RS14405 (2883887) | 2883887..2884294 | + | 408 | WP_000695734.1 | hypothetical protein | - |
| IF738_RS14410 (2884294) | 2884294..2884569 | + | 276 | WP_072473441.1 | hypothetical protein | - |
| IF738_RS14415 (2884562) | 2884562..2884813 | + | 252 | WP_086097839.1 | DUF1024 family protein | Toxin |
| IF738_RS14420 (2884803) | 2884803..2884985 | + | 183 | WP_086097840.1 | hypothetical protein | Antitoxin |
| IF738_RS14425 (2884978) | 2884978..2885514 | + | 537 | WP_000185680.1 | dUTPase | - |
| IF738_RS14430 (2885551) | 2885551..2885796 | + | 246 | WP_001282070.1 | hypothetical protein | - |
| IF738_RS14435 (2885793) | 2885793..2885999 | + | 207 | WP_031838300.1 | DUF1381 domain-containing protein | - |
| IF738_RS14440 (2885996) | 2885996..2886145 | + | 150 | WP_031761843.1 | transcriptional regulator | - |
| IF738_RS14445 (2886145) | 2886145..2886345 | + | 201 | WP_240024521.1 | DUF1514 family protein | - |
| IF738_RS14450 (2886368) | 2886368..2886847 | + | 480 | WP_000282747.1 | hypothetical protein | - |
| IF738_RS14455 (2886962) | 2886962..2887414 | + | 453 | WP_000406191.1 | nucleoside triphosphate pyrophosphohydrolase family protein | - |
| IF738_RS14460 (2887430) | 2887430..2887774 | + | 345 | WP_000817289.1 | HNH endonuclease | - |
| IF738_RS14465 (2887904) | 2887904..2888371 | + | 468 | WP_000919026.1 | phage terminase small subunit P27 family | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | geh | 2857954..2888371 | 30417 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9527.44 Da Isoelectric Point: 3.7128
>T174495 WP_086097839.1 NZ_CP062348:2884562-2884813 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDIYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEY
MNNREQIEQSVISASAYNGNDTEGLLKEIEDIYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTSQVVYKYEEEQE
NEY
Download Length: 252 bp
>T174495 NZ_CP081016:316665-316970 [Pseudomonas sp. 2hn]
ATGACAGATCTCAAGCTGACCAAGTGGGACGCTGCGGACCATTTGCAGACCGAGGAAGATATCGTCCTCTATCTTGAGGC
GTGCCTGGAGGAGAACGATCCGACGCTGCTTGCCGCCGCGTTGGGGGATATCGCCCGTGCCCGCGGCATGGCCCAGTTGG
CTCGTGATACCGGCTTGACCCGGGAGGGTCTGTACAAGGCGCTGTCTGCGGATGGAAACCCCAGCCTGGCAACCATCATG
AAAGTCATGGCGGCGCTCGGGGTCCGGCTGCACGCAGAGATCGTAACTCCGCGGGCGGCGGGGTAG
ATGACAGATCTCAAGCTGACCAAGTGGGACGCTGCGGACCATTTGCAGACCGAGGAAGATATCGTCCTCTATCTTGAGGC
GTGCCTGGAGGAGAACGATCCGACGCTGCTTGCCGCCGCGTTGGGGGATATCGCCCGTGCCCGCGGCATGGCCCAGTTGG
CTCGTGATACCGGCTTGACCCGGGAGGGTCTGTACAAGGCGCTGTCTGCGGATGGAAACCCCAGCCTGGCAACCATCATG
AAAGTCATGGCGGCGCTCGGGGTCCGGCTGCACGCAGAGATCGTAACTCCGCGGGCGGCGGGGTAG
Antitoxin
Download Length: 61 a.a. Molecular weight: 6793.71 Da Isoelectric Point: 4.4421
>AT174495 WP_086097840.1 NZ_CP062348:2884803-2884985 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDIHYKLSDGSIISLIDFVIKPIHLIKEAQEND
MSISVGDKVYNHETNESLEIVQLVGDIRDIHYKLSDGSIISLIDFVIKPIHLIKEAQEND
Download Length: 183 bp
>AT174495 NZ_CP081016:316365-316655 [Pseudomonas sp. 2hn]
ATGCACACGCTCATACAGACCGACATGTACAGGAAGTGGTTTGCCGCCTTGCGGGATGCGCGTGCGCAAGCTCGCATCAA
CGTGCGGCTGCGGCGGGTCGAGCTTGGAGTGCTGGGTGATTGTAAGCCGGTGGGTGAGGGTGTCTTCGAGTTGAGGATCG
ACTACGGTCCGGGCTATCGGGTCTATCTGGCTCGGCGGGGTTACGAAGTGATCATCCTCCTGGCAGGAGGAGACAAAGCC
ACCCAGGCCAGGGACATCAAATCTGCACTCAGGCTGGCGCGCAATCTTTAG
ATGCACACGCTCATACAGACCGACATGTACAGGAAGTGGTTTGCCGCCTTGCGGGATGCGCGTGCGCAAGCTCGCATCAA
CGTGCGGCTGCGGCGGGTCGAGCTTGGAGTGCTGGGTGATTGTAAGCCGGTGGGTGAGGGTGTCTTCGAGTTGAGGATCG
ACTACGGTCCGGGCTATCGGGTCTATCTGGCTCGGCGGGGTTACGAAGTGATCATCCTCCTGGCAGGAGGAGACAAAGCC
ACCCAGGCCAGGGACATCAAATCTGCACTCAGGCTGGCGCGCAATCTTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|