174494

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2239502..2240025 Replicon chromosome
Accession NZ_CP062348
Organism Staphylococcus aureus strain NAS_AN_260

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag IF738_RS11425 Protein ID WP_000074048.1
Coordinates 2239502..2239768 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag IF738_RS11430 Protein ID WP_000587616.1
Coordinates 2239768..2240025 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF738_RS11405 (2234808) 2234808..2235995 - 1188 WP_000026194.1 MFS transporter -
IF738_RS11410 (2236391) 2236391..2237167 - 777 WP_000072145.1 iron export ABC transporter permease subunit FetB -
IF738_RS11415 (2237160) 2237160..2237822 - 663 WP_000923523.1 ATP-binding cassette domain-containing protein -
IF738_RS11420 (2238070) 2238070..2239146 - 1077 WP_001076671.1 M42 family metallopeptidase -
IF738_RS11425 (2239502) 2239502..2239768 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
IF738_RS11430 (2239768) 2239768..2240025 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF738_RS11435 (2240384) 2240384..2240839 + 456 WP_000732082.1 DUF1307 domain-containing protein -
IF738_RS11440 (2241007) 2241007..2242584 - 1578 WP_000143496.1 FMN-binding glutamate synthase family protein -
IF738_RS11445 (2242780) 2242780..2243529 + 750 WP_000072445.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T174494 WP_000074048.1 NZ_CP062348:c2239768-2239502 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174494 NZ_CP081016:316365-316655 [Pseudomonas sp. 2hn]
ATGCACACGCTCATACAGACCGACATGTACAGGAAGTGGTTTGCCGCCTTGCGGGATGCGCGTGCGCAAGCTCGCATCAA
CGTGCGGCTGCGGCGGGTCGAGCTTGGAGTGCTGGGTGATTGTAAGCCGGTGGGTGAGGGTGTCTTCGAGTTGAGGATCG
ACTACGGTCCGGGCTATCGGGTCTATCTGGCTCGGCGGGGTTACGAAGTGATCATCCTCCTGGCAGGAGGAGACAAAGCC
ACCCAGGCCAGGGACATCAAATCTGCACTCAGGCTGGCGCGCAATCTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT174494 WP_000587616.1 NZ_CP062348:c2240025-2239768 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174494 NZ_CP081016:316665-316970 [Pseudomonas sp. 2hn]
ATGACAGATCTCAAGCTGACCAAGTGGGACGCTGCGGACCATTTGCAGACCGAGGAAGATATCGTCCTCTATCTTGAGGC
GTGCCTGGAGGAGAACGATCCGACGCTGCTTGCCGCCGCGTTGGGGGATATCGCCCGTGCCCGCGGCATGGCCCAGTTGG
CTCGTGATACCGGCTTGACCCGGGAGGGTCTGTACAAGGCGCTGTCTGCGGATGGAAACCCCAGCCTGGCAACCATCATG
AAAGTCATGGCGGCGCTCGGGGTCCGGCTGCACGCAGAGATCGTAACTCCGCGGGCGGCGGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References