Detailed information of TA system TA174492

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2208312..2208496
• Replicon: chromosome
• Accession: NZ_CP062348
• Organism: Staphylococcus aureus strain NAS_AN_260

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF738_RS11285
• Protein ID: WP_000482647.1
• Coordinates: 2208389..2208496 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2208312..2208372 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF738_RS11270	2203786..2203953	-	168	WP_001790576.1	hypothetical protein	-
IF738_RS11275	2204184..2205917	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
IF738_RS11280	2205942..2207705	-	1764	WP_001064816.1	ABC transporter ATP-binding protein	-
-	2208312..2208372	+	61	-	-	Antitoxin
IF738_RS11285	2208389..2208496	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
IF738_RS11290	2208630..2209016	-	387	WP_240024492.1	flippase GtxA	-
IF738_RS11295	2209274..2210416	+	1143	WP_001176871.1	glycerate kinase	-
IF738_RS11300	2210476..2211135	+	660	WP_000831301.1	membrane protein	-
IF738_RS11305	2211317..2212528	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF738_RS11310	2212651..2213124	-	474	WP_000456497.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174492 WP_000482647.1 NZ_CP062348:c2208496-2208389 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174492 NZ_CP081016:c131410-131126 [Pseudomonas sp. 2hn]
ATGCATGTACTGACTTTTAGCCAAGCTCGCGCCGACCTGAAGCAAACGATGGATGACGTATGCCGCGACCACGAGCCGGC
GATCATCACGCGCCAACGTGGCGAGCCGGTGGTCATGCTGTCCCTGGAGGATTACAACGGCATGCAGGAGACCCTTTACT
TGCTAGGGTCTTCTGCCAACGCAAGGCGCTTGCGTTCATCAGTCGAGCAGCTGCGGTCGGGTCAGCCAGTTACTCAAGAG
CTGATCATCGATGAACATGAAGTCAAAGCAACGCAACAAGACTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174492 NZ_CP062348:2208312-2208372 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin