Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2182954..2183471 | Replicon | chromosome |
| Accession | NZ_CP062348 | ||
| Organism | Staphylococcus aureus strain NAS_AN_260 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | IF738_RS11150 | Protein ID | WP_000113262.1 |
| Coordinates | 2182954..2183220 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | IF738_RS11155 | Protein ID | WP_000584499.1 |
| Coordinates | 2183220..2183471 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF738_RS11120 (2178379) | 2178379..2178906 | - | 528 | WP_000973468.1 | GNAT family N-acetyltransferase | - |
| IF738_RS11125 (2179150) | 2179150..2179974 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| IF738_RS11130 (2180191) | 2180191..2180373 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| IF738_RS11135 (2180457) | 2180457..2180924 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| IF738_RS11140 (2181110) | 2181110..2182660 | - | 1551 | WP_000727755.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| IF738_RS11145 (2182848) | 2182848..2182919 | - | 72 | WP_223200558.1 | hypothetical protein | - |
| IF738_RS11150 (2182954) | 2182954..2183220 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| IF738_RS11155 (2183220) | 2183220..2183471 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| IF738_RS11160 (2183636) | 2183636..2183716 | - | 81 | WP_223197974.1 | hypothetical protein | - |
| IF738_RS11165 (2183744) | 2183744..2184343 | - | 600 | WP_000162810.1 | DsbA family protein | - |
| IF738_RS11170 (2184362) | 2184362..2184724 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| IF738_RS11175 (2184979) | 2184979..2186229 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| IF738_RS11180 (2186326) | 2186326..2187057 | - | 732 | WP_000615458.1 | ATP-binding cassette domain-containing protein | - |
| IF738_RS11185 (2187054) | 2187054..2187773 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T174491 WP_000113262.1 NZ_CP062348:c2183220-2182954 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174491 NZ_CP081016:c131112-130855 [Pseudomonas sp. 2hn]
GTGAGCGTTGCGTTCACTGCCGAGGGATGGGAAGACTATCACCACTGGCGGGAAGCTGATTCGGCGATCTTCGAGACGGT
CAATGTGCTGATCCGCGAGTGCTGCCGTACACCCTTCAAAGGGACTGGTAAACCTGAGCCGCTCAAGGGCGATCTTTCCG
GGTTCTGGTCTCGTCGCATCACCCGAGAGCACCGTCTGGTCTACTTCTATGAAGGTGGCCAGTTGACTGTACTTCAATGT
CGGTTCCACTACGACTGA
GTGAGCGTTGCGTTCACTGCCGAGGGATGGGAAGACTATCACCACTGGCGGGAAGCTGATTCGGCGATCTTCGAGACGGT
CAATGTGCTGATCCGCGAGTGCTGCCGTACACCCTTCAAAGGGACTGGTAAACCTGAGCCGCTCAAGGGCGATCTTTCCG
GGTTCTGGTCTCGTCGCATCACCCGAGAGCACCGTCTGGTCTACTTCTATGAAGGTGGCCAGTTGACTGTACTTCAATGT
CGGTTCCACTACGACTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174491 WP_000584499.1 NZ_CP062348:c2183471-2183220 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174491 NZ_CP081016:c131410-131126 [Pseudomonas sp. 2hn]
ATGCATGTACTGACTTTTAGCCAAGCTCGCGCCGACCTGAAGCAAACGATGGATGACGTATGCCGCGACCACGAGCCGGC
GATCATCACGCGCCAACGTGGCGAGCCGGTGGTCATGCTGTCCCTGGAGGATTACAACGGCATGCAGGAGACCCTTTACT
TGCTAGGGTCTTCTGCCAACGCAAGGCGCTTGCGTTCATCAGTCGAGCAGCTGCGGTCGGGTCAGCCAGTTACTCAAGAG
CTGATCATCGATGAACATGAAGTCAAAGCAACGCAACAAGACTGA
ATGCATGTACTGACTTTTAGCCAAGCTCGCGCCGACCTGAAGCAAACGATGGATGACGTATGCCGCGACCACGAGCCGGC
GATCATCACGCGCCAACGTGGCGAGCCGGTGGTCATGCTGTCCCTGGAGGATTACAACGGCATGCAGGAGACCCTTTACT
TGCTAGGGTCTTCTGCCAACGCAAGGCGCTTGCGTTCATCAGTCGAGCAGCTGCGGTCGGGTCAGCCAGTTACTCAAGAG
CTGATCATCGATGAACATGAAGTCAAAGCAACGCAACAAGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|