Detailed information of TA system TA174472

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2652493..2652756
• Replicon: chromosome
• Accession: NZ_CP062346
• Organism: Staphylococcus aureus strain NAS_AN_261

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF739_RS13080
• Protein ID: WP_001802298.1
• Coordinates: 2652493..2652597 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2652592..2652756 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF739_RS13055	2647902..2648684	+	783	WP_240017953.1	ABC transporter ATP-binding protein	-
IF739_RS13060	2648752..2649609	+	858	WP_000370936.1	HAD family hydrolase	-
IF739_RS13070	2650658..2651785	+	1128	WP_047213687.1	SAP domain-containing protein	-
IF739_RS13075	2651892..2652332	+	441	Protein_2538	recombinase family protein	-
IF739_RS13080	2652493..2652597	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2652592..2652756	-	165	-	-	Antitoxin
IF739_RS13090	2653103..2654194	-	1092	WP_047213685.1	hypothetical protein	-
IF739_RS13095	2654460..2655440	-	981	WP_000019739.1	CDF family zinc efflux transporter CzrB	-
IF739_RS13100	2655442..2655762	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF739_RS13105	2655914..2656579	+	666	WP_001024091.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174472 WP_001802298.1 NZ_CP062346:2652493-2652597 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174472 NZ_CP081010:1918835-1919086 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 165 bp

>AT174472 NZ_CP062346:c2652756-2652592 [Staphylococcus aureus]
GTAGTAAGTAGAAGTAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin