Detailed information of TA system TA174471

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2394028..2394545
• Replicon: chromosome
• Accession: NZ_CP062346
• Organism: Staphylococcus aureus strain NAS_AN_261

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A2S6D1N9
• Locus tag: IF739_RS11740
• Protein ID: WP_000113263.1
• Coordinates: 2394279..2394545 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: IF739_RS11735
• Protein ID: WP_221572860.1
• Coordinates: 2394028..2394279 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF739_RS11705 (2389727)	2389727..2390446	+	720	WP_000479576.1	amino acid ABC transporter permease	-
IF739_RS11710 (2390443)	2390443..2391174	+	732	WP_000615459.1	amino acid ABC transporter ATP-binding protein	-
IF739_RS11715 (2391271)	2391271..2392521	-	1251	WP_001012216.1	FemA/FemB family glycyltransferase FmhA	-
IF739_RS11720 (2392776)	2392776..2393138	+	363	WP_000819846.1	DUF4467 domain-containing protein	-
IF739_RS11725 (2393157)	2393157..2393756	+	600	WP_000162805.1	DsbA family protein	-
IF739_RS11730 (2393763)	2393763..2393863	+	101	Protein_2279	hypothetical protein	-
IF739_RS11735 (2394028)	2394028..2394279	+	252	WP_221572860.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF739_RS11740 (2394279)	2394279..2394545	+	267	WP_000113263.1	Txe/YoeB family addiction module toxin	Toxin
IF739_RS11745 (2394838)	2394838..2396385	+	1548	WP_047212937.1	zinc ABC transporter substrate-binding lipoprotein AdcA	-
IF739_RS11750 (2396571)	2396571..2397038	+	468	WP_000153349.1	SRPBCC domain-containing protein	-
IF739_RS11755 (2397125)	2397125..2397307	+	183	WP_000079140.1	hypothetical protein	-
IF739_RS11760 (2397510)	2397510..2398334	+	825	WP_000594640.1	formate/nitrite transporter family protein	-
IF739_RS11765 (2398747)	2398747..2399283	+	537	WP_000185898.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (8-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10437.01 Da
• Isoelectric Point: 10.1628

>T174471 WP_000113263.1 NZ_CP062346:2394279-2394545 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Nucleotide

• Length: 267 bp

>T174471 NZ_CP081010:1212891-1213202 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTGTGCGCGCAAATATCCTAACGACGCTCTGGCTCTACACTCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAAATGCGAACGGCTTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATCACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9447.63 Da
• Isoelectric Point: 4.3407

>AT174471 WP_221572860.1 NZ_CP062346:2394028-2394279 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNIVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Nucleotide

• Length: 252 bp

>AT174471 NZ_CP081010:1213199-1213618 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGTGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCAGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGCCAGATCTTGTCTGGACAACGATCCTTGACGATACCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Structures

Toxin

• AlphaFold DB: A0A2S6D1N9