Detailed information of TA system TA174469

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2369033..2369217
• Replicon: chromosome
• Accession: NZ_CP062346
• Organism: Staphylococcus aureus strain NAS_AN_261

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: IF739_RS11605
• Protein ID: WP_000482647.1
• Coordinates: 2369033..2369140 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2369157..2369217 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF739_RS11580	2364404..2364877	+	474	WP_000456493.1	GyrI-like domain-containing protein	-
IF739_RS11585	2365000..2366211	-	1212	WP_001191927.1	multidrug effflux MFS transporter	-
IF739_RS11590	2366384..2367043	-	660	WP_031927729.1	membrane protein	-
IF739_RS11595	2367103..2368245	-	1143	WP_240017933.1	glycerate kinase	-
IF739_RS11600	2368513..2368899	+	387	WP_000779353.1	flippase GtxA	-
IF739_RS11605	2369033..2369140	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2369157..2369217	-	61	-	-	Antitoxin
IF739_RS11610	2369844..2371607	+	1764	WP_031927727.1	ABC transporter ATP-binding protein	-
IF739_RS11615	2371632..2373365	+	1734	WP_000486497.1	ABC transporter ATP-binding protein	-
IF739_RS11620	2373596..2373763	+	168	WP_031927726.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T174469 WP_000482647.1 NZ_CP062346:2369033-2369140 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174469 NZ_CP081010:c830485-830108 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCAACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCAGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174469 NZ_CP062346:c2369217-2369157 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin