Detailed information of TA system TA174462

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 19380..19718
• Replicon: chromosome
• Accession: NZ_CP062346
• Organism: Staphylococcus aureus strain NAS_AN_261

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: A0A6B5C9Y4
• Locus tag: IF739_RS00095
• Protein ID: WP_072357969.1
• Coordinates: 19380..19556 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19544..19718 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF739_RS00075	14546..18331	+	3786	WP_240017971.1	phage tail spike protein	-
IF739_RS00080	18321..18473	+	153	WP_000654329.1	hypothetical protein	-
IF739_RS00085	18520..18807	+	288	WP_001040255.1	hypothetical protein	-
IF739_RS00090	18863..19237	+	375	WP_000340977.1	hypothetical protein	-
IF739_RS00095	19380..19556	+	177	WP_072357969.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19544..19718	-	175	-	-	Antitoxin
IF739_RS00105	19768..20022	+	255	WP_000611512.1	phage holin	-
IF739_RS00110	20034..20789	+	756	WP_000861027.1	CHAP domain-containing protein	-
IF739_RS00115	20980..21471	+	492	WP_000920038.1	staphylokinase	-
IF739_RS00120	22122..22457	+	336	Protein_23	SH3 domain-containing protein	-
IF739_RS00125	22968..23318	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
IF739_RS00130	23370..23630	-	261	WP_001791826.1	hypothetical protein	-
IF739_RS00135	23941..24120	-	180	WP_000669791.1	hypothetical protein	-
IF739_RS00140	24481..24678	-	198	WP_000239610.1	phospholipase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1..23318	23317

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6863.47 Da
• Isoelectric Point: 10.6777

>T174462 WP_072357969.1 NZ_CP062346:19380-19556 [Staphylococcus aureus]
MDRWWLSEYKEVVPMLALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174462 NZ_CP081009:4282859-4283146 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174462 NZ_CP062346:c19718-19544 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• AlphaFold DB: A0A6B5C9Y4

Antitoxin