Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 2378174..2378691 | Replicon | chromosome |
Accession | NZ_CP062344 | ||
Organism | Staphylococcus aureus strain NAS_AN_265 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | T1YC79 |
Locus tag | IF740_RS11740 | Protein ID | WP_000113262.1 |
Coordinates | 2378425..2378691 (+) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | T1YB60 |
Locus tag | IF740_RS11735 | Protein ID | WP_000584499.1 |
Coordinates | 2378174..2378425 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IF740_RS11705 (2373872) | 2373872..2374591 | + | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
IF740_RS11710 (2374588) | 2374588..2375319 | + | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
IF740_RS11715 (2375416) | 2375416..2376666 | - | 1251 | WP_001012227.1 | FemA/FemB family glycyltransferase FmhA | - |
IF740_RS11720 (2376921) | 2376921..2377283 | + | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
IF740_RS11725 (2377302) | 2377302..2377901 | + | 600 | WP_000162813.1 | DsbA family protein | - |
IF740_RS11730 (2377908) | 2377908..2378009 | + | 102 | WP_001791744.1 | hypothetical protein | - |
IF740_RS11735 (2378174) | 2378174..2378425 | + | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
IF740_RS11740 (2378425) | 2378425..2378691 | + | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
IF740_RS11745 (2378726) | 2378726..2378797 | + | 72 | Protein_2282 | hypothetical protein | - |
IF740_RS11750 (2378986) | 2378986..2380536 | + | 1551 | WP_000727763.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
IF740_RS11755 (2380722) | 2380722..2381189 | + | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
IF740_RS11760 (2381273) | 2381273..2381455 | + | 183 | WP_000230294.1 | hypothetical protein | - |
IF740_RS11765 (2381672) | 2381672..2382496 | + | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
IF740_RS11770 (2382729) | 2382729..2383265 | + | 537 | WP_000169317.1 | GNAT family N-acetyltransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T174455 WP_000113262.1 NZ_CP062344:2378425-2378691 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T174455 NZ_CP081009:3888360-3888665 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT174455 WP_000584499.1 NZ_CP062344:2378174-2378425 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT174455 NZ_CP081009:3888140-3888358 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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