Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2378174..2378691 Replicon chromosome
Accession NZ_CP062344
Organism Staphylococcus aureus strain NAS_AN_265

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag IF740_RS11740 Protein ID WP_000113262.1
Coordinates 2378425..2378691 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag IF740_RS11735 Protein ID WP_000584499.1
Coordinates 2378174..2378425 (+) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF740_RS11705 (2373872) 2373872..2374591 + 720 WP_000479576.1 amino acid ABC transporter permease -
IF740_RS11710 (2374588) 2374588..2375319 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
IF740_RS11715 (2375416) 2375416..2376666 - 1251 WP_001012227.1 FemA/FemB family glycyltransferase FmhA -
IF740_RS11720 (2376921) 2376921..2377283 + 363 WP_000819843.1 DUF4467 domain-containing protein -
IF740_RS11725 (2377302) 2377302..2377901 + 600 WP_000162813.1 DsbA family protein -
IF740_RS11730 (2377908) 2377908..2378009 + 102 WP_001791744.1 hypothetical protein -
IF740_RS11735 (2378174) 2378174..2378425 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF740_RS11740 (2378425) 2378425..2378691 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
IF740_RS11745 (2378726) 2378726..2378797 + 72 Protein_2282 hypothetical protein -
IF740_RS11750 (2378986) 2378986..2380536 + 1551 WP_000727763.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
IF740_RS11755 (2380722) 2380722..2381189 + 468 WP_000153344.1 SRPBCC domain-containing protein -
IF740_RS11760 (2381273) 2381273..2381455 + 183 WP_000230294.1 hypothetical protein -
IF740_RS11765 (2381672) 2381672..2382496 + 825 WP_000572040.1 formate/nitrite transporter family protein -
IF740_RS11770 (2382729) 2382729..2383265 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T174455 WP_000113262.1 NZ_CP062344:2378425-2378691 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T174455 NZ_CP081009:3888360-3888665 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT174455 WP_000584499.1 NZ_CP062344:2378174-2378425 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT174455 NZ_CP081009:3888140-3888358 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E


Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References