Detailed information of TA system TA174453

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2353132..2353316
• Replicon: chromosome
• Accession: NZ_CP062344
• Organism: Staphylococcus aureus strain NAS_AN_265

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2U0ISP5
• Locus tag: IF740_RS11605
• Protein ID: WP_000482652.1
• Coordinates: 2353132..2353239 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2353256..2353316 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF740_RS11580	2348494..2348967	+	474	WP_000456484.1	GyrI-like domain-containing protein	-
IF740_RS11585	2349090..2350301	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
IF740_RS11590	2350483..2351142	-	660	WP_000831298.1	membrane protein	-
IF740_RS11595	2351202..2352344	-	1143	WP_001176863.1	glycerate kinase	-
IF740_RS11600	2352612..2352998	+	387	WP_000779357.1	flippase GtxA	-
IF740_RS11605	2353132..2353239	+	108	WP_000482652.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2353256..2353316	-	61	-	-	Antitoxin
IF740_RS11610	2353886..2355649	+	1764	WP_001064809.1	ABC transporter ATP-binding protein	-
IF740_RS11615	2355674..2357407	+	1734	WP_031918671.1	ABC transporter ATP-binding protein	-
IF740_RS11620	2357674..2357805	+	132	WP_223876853.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T174453 WP_000482652.1 NZ_CP062344:2353132-2353239 [Staphylococcus aureus]
MFNLLINIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T174453 NZ_CP081009:3696264-3696662 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGGTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCTTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174453 NZ_CP062344:c2353316-2353256 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2U0ISP5

Antitoxin