Detailed information of TA system TA174445

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 180868..181048
• Replicon: chromosome
• Accession: NZ_CP062344
• Organism: Staphylococcus aureus strain NAS_AN_265

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF740_RS01110
• Protein ID: WP_001801861.1
• Coordinates: 180953..181048 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	180868..180925 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF740_RS01080	176576..176710	+	135	Protein_176	hypothetical protein	-
IF740_RS01085	176875..178431	+	1557	WP_000028583.1	type I restriction-modification system subunit M	-
IF740_RS01090	178424..179653	+	1230	WP_047230715.1	restriction endonuclease subunit S	-
IF740_RS01095	180195..180605	+	411	WP_001808705.1	IS21 family transposase	-
IF740_RS01100	180590..180751	+	162	Protein_180	transposase	-
IF740_RS01105	180729..180830	-	102	WP_001792025.1	hypothetical protein	-
-	180868..180925	+	58	-	-	Antitoxin
IF740_RS01110	180953..181048	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF740_RS01115	181193..182205	+	1013	Protein_183	IS3 family transposase	-
IF740_RS01120	182404..182976	-	573	WP_000414215.1	hypothetical protein	-
IF740_RS01125	183077..183418	-	342	WP_000627537.1	DUF3969 family protein	-
IF740_RS01130	183459..184085	-	627	WP_000669026.1	hypothetical protein	-
IF740_RS01135	184160..185155	-	996	WP_000070641.1	DUF4352 domain-containing protein	-
IF740_RS01140	185236..185886	-	651	WP_072470537.1	excalibur calcium-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / hlgA / lukD	145480..186644	41164

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174445 WP_001801861.1 NZ_CP062344:c181048-180953 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174445 NZ_CP081009:2276128-2277201 [Escherichia coli]
ATGACAATCAGGAGTTACAAAAACTTAAATCTGGTCAGGGCAAATATCGAGACTGAATCCAGACAATTCATTGAAAATAA
AAACTATTCAATCCAATCAATTGGTCCTATGCCAGGGTCAAGGGCTGGGCTTCGGGTCGTATTTACCAGACCAGGGGTTA
ACTTGGCAACTGTGGACATTTTTTATAACGGGGACGGTTCGACTACAATTCAATATCTCACTGGAGCCAATCGTTCTCTG
GGCCAAGAGTTAGCGGATCATCTTTTTGAAACCATCAATCCTGCTGAATTTGAGCAGGTAAATATGGTACTGCAAGGATT
TGTAGAGACAAGCGTTCTACCTGTACTTGAGCTATCAGCAGATGAATCGCATATAGAGTTCAGAGAACACTCTCGTAACG
CTCATACCGTAGTGTGGAAAATTATTTCCACCAGCTATCAGGACGAATTGACTGTGAGCCTGCATATCACAACAGGTAAG
CTCCAGATTCAGGGCCGACCGCTGTCATGTTACAGAGTTTTCACGTTTAACTTGGCAGCCCTGCTTGATTTACAGGGTTT
GGAGAAAGTGCTAATCCGCCAGGAGGATGGTAAAGCTAATATTGTTCAACAGGAGGTTGCCCGCACTTACTTGCAGACTG
TAATGGCCGATGCTTACCCGCATCTCCACGTGACTGCCGAAAAATTGCTCGTTTCAGGGCTATGTGTTAAACTCGCCGCC
CCTGATTTGCCTGACTACTGTATGTTACTTTATCCTGAACTACGCACCATTGAAGGTGTCTTAAAAAGTAAGATGAGTGG
GTTAGGCATGCCAGTACAGCAGCCGGCAGGTTTTGGAACTTACTTTGATAAACCTGCTGCTCATTACATTCTGAAACCGC
AATTTGCAGCTACTCTTAGACCGGAACAGATTAACATCATCAGCACAGCCTATACTTTTTTTAATGTGGAACGTCATTCT
CTGTTCCACATGGAAACTGTGGTCGATGCCAGCCGTATGATTTCTGATATGGCCCGGTTGATGGGTAAAGCCACTAGAGC
GTGGGGAATAATCAAGGACTTATATATTGTTTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174445 NZ_CP062344:180868-180925 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin