Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2627710..2627988 Replicon chromosome
Accession NZ_CP062342
Organism Staphylococcus aureus strain NAS_AN_270

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag IF741_RS13005 Protein ID WP_001802298.1
Coordinates 2627710..2627814 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF3
Locus tag -
Coordinates 2627810..2627988 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF741_RS12990 2624507..2625289 + 783 WP_000908189.1 ABC transporter ATP-binding protein -
IF741_RS12995 2625357..2626214 + 858 WP_000370928.1 HAD family hydrolase -
IF741_RS13000 2626872..2627030 - 159 WP_001792784.1 hypothetical protein -
IF741_RS13005 2627710..2627814 + 105 WP_001802298.1 hypothetical protein Toxin
- 2627810..2627988 - 179 - - Antitoxin
IF741_RS13015 2628256..2629347 - 1092 WP_000495681.1 hypothetical protein -
IF741_RS13020 2629613..2630593 - 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
IF741_RS13025 2630595..2630915 - 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
IF741_RS13030 2631067..2631732 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T174436 WP_001802298.1 NZ_CP062342:2627710-2627814 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T174436 NZ_CP081008:4057678-4057785 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 179 bp

>AT174436 NZ_CP062342:c2627988-2627810 [Staphylococcus aureus]
GTGTTAAAATATATTTGTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGG
AAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCA
AAGCGAATAGAAGGTTATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References