Detailed information of TA system TA174432

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2349447..2349631
• Replicon: chromosome
• Accession: NZ_CP062342
• Organism: Staphylococcus aureus strain NAS_AN_270

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: -
• Locus tag: IF741_RS11550
• Protein ID: WP_072467491.1
• Coordinates: 2349447..2349554 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2349571..2349631 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF741_RS11525	2344820..2345293	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
IF741_RS11530	2345416..2346627	-	1212	WP_240026396.1	multidrug effflux MFS transporter	-
IF741_RS11535	2346809..2347468	-	660	WP_000831298.1	membrane protein	-
IF741_RS11540	2347528..2348670	-	1143	WP_064129935.1	glycerate kinase	-
IF741_RS11545	2348927..2349313	+	387	WP_000779348.1	flippase GtxA	-
IF741_RS11550	2349447..2349554	+	108	WP_072467491.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	2349571..2349631	-	61	-	-	Antitoxin
IF741_RS11555	2350144..2351907	+	1764	WP_001064834.1	ABC transporter ATP-binding protein	-
IF741_RS11560	2351932..2353665	+	1734	WP_000486502.1	ABC transporter ATP-binding protein	-
IF741_RS11565	2353896..2354063	+	168	WP_031866196.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3944.67 Da
• Isoelectric Point: 10.4934

>T174432 WP_072467491.1 NZ_CP062342:2349447-2349554 [Staphylococcus aureus]
IFNLLIDIMTSAISGCLVAFFANWLRTRSNKKGDK

Nucleotide

• Length: 108 bp

>T174432 NZ_CP081008:3706830-3707135 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT174432 NZ_CP062342:c2349631-2349571 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Antitoxin