Detailed information of TA system TA174431

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 2318089..2318612
• Replicon: chromosome
• Accession: NZ_CP062342
• Organism: Staphylococcus aureus strain NAS_AN_270

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: IF741_RS11420
• Protein ID: WP_000074046.1
• Coordinates: 2318346..2318612 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A2K4AGF2
• Locus tag: IF741_RS11415
• Protein ID: WP_000587615.1
• Coordinates: 2318089..2318346 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF741_RS11395 (2313184)	2313184..2314377	+	1194	WP_000675403.1	MFS transporter	-
IF741_RS11400 (2314601)	2314601..2315350	-	750	WP_000019956.1	CPBP family lipoprotein N-acylation protein LnsB	-
IF741_RS11405 (2315540)	2315540..2317117	+	1578	WP_000143490.1	FMN-binding glutamate synthase family protein	-
IF741_RS11410 (2317267)	2317267..2317731	-	465	WP_000736689.1	DUF1307 domain-containing protein	-
IF741_RS11415 (2318089)	2318089..2318346	+	258	WP_000587615.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IF741_RS11420 (2318346)	2318346..2318612	+	267	WP_000074046.1	Txe/YoeB family addiction module toxin	Toxin
IF741_RS11425 (2318925)	2318925..2320001	+	1077	WP_001076667.1	M42 family metallopeptidase	-
IF741_RS11430 (2320249)	2320249..2320911	+	663	WP_000923528.1	ATP-binding cassette domain-containing protein	-
IF741_RS11435 (2320904)	2320904..2321677	+	774	WP_000072148.1	iron export ABC transporter permease subunit FetB	-
IF741_RS11440 (2322029)	2322029..2323213	+	1185	WP_000115415.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10658.27 Da
• Isoelectric Point: 10.1384

>T174431 WP_000074046.1 NZ_CP062342:2318346-2318612 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T174431 NZ_CP081008:3547517-3547915 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGGTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCTTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9746.68 Da
• Isoelectric Point: 4.1111

>AT174431 WP_000587615.1 NZ_CP062342:2318089-2318346 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT174431 NZ_CP081008:3547290-3547517 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A2K4AGF2