Detailed information of TA system TA174428

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 167723..167903
• Replicon: chromosome
• Accession: NZ_CP062342
• Organism: Staphylococcus aureus strain NAS_AN_270

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: IF741_RS01050
• Protein ID: WP_001801861.1
• Coordinates: 167808..167903 (-)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	167723..167780 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF741_RS01020	164074..165192	+	1119	WP_000072558.1	restriction endonuclease subunit S	-
IF741_RS01025	165840..166283	+	444	WP_000742594.1	DUF1433 domain-containing protein	-
IF741_RS01030	166562..166840	+	279	WP_001798632.1	DUF1433 domain-containing protein	-
IF741_RS01035	166862..167236	+	375	WP_000695818.1	DUF1433 domain-containing protein	-
IF741_RS01040	167424..167606	+	183	Protein_170	transposase	-
IF741_RS01045	167584..167685	-	102	WP_001791232.1	hypothetical protein	-
-	167723..167780	+	58	-	-	Antitoxin
IF741_RS01050	167808..167903	-	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
IF741_RS01055	168354..168800	+	447	WP_000747802.1	DUF1433 domain-containing protein	-
IF741_RS01060	169485..169868	+	384	WP_000070811.1	hypothetical protein	-
IF741_RS01065	169879..170055	+	177	WP_000375476.1	hypothetical protein	-
IF741_RS01070	170355..170983	+	629	Protein_176	ImmA/IrrE family metallo-endopeptidase	-
IF741_RS01075	171181..171753	-	573	Protein_177	hypothetical protein	-
IF741_RS01080	171854..172195	-	342	WP_000627548.1	DUF3969 family protein	-
IF741_RS01085	172236..172862	-	627	WP_000669019.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlgA / lukD	146186..175422	29236

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T174428 WP_001801861.1 NZ_CP062342:c167903-167808 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T174428 NZ_CP081008:3047267-3047608 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT174428 NZ_CP062342:167723-167780 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin