Detailed information of TA system TA174424

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18831..19169
• Replicon: chromosome
• Accession: NZ_CP062342
• Organism: Staphylococcus aureus strain NAS_AN_270

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: IF741_RS00105
• Protein ID: WP_011447039.1
• Coordinates: 18831..19007 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	18995..19169 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF741_RS00085	14066..17851	+	3786	WP_240026403.1	phage tail spike protein	-
IF741_RS00090	17841..17993	+	153	WP_001153681.1	hypothetical protein	-
IF741_RS00095	18040..18327	+	288	WP_001040254.1	hypothetical protein	-
IF741_RS00100	18385..18681	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
IF741_RS00105	18831..19007	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	18995..19169	-	175	-	-	Antitoxin
IF741_RS00115	19219..19473	+	255	WP_000611512.1	phage holin	-
IF741_RS00120	19485..20240	+	756	WP_000861038.1	CHAP domain-containing protein	-
IF741_RS00125	20431..20922	+	492	WP_000920042.1	staphylokinase	-
IF741_RS00130	21740..22534	+	795	WP_000238962.1	phosphatidylinositol kinase	-
IF741_RS00135	22541..23278	+	738	WP_000278828.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / scn	1..24537	24536

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T174424 WP_011447039.1 NZ_CP062342:18831-19007 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T174424 NZ_CP081008:2678768-2679097 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Nucleotide

• Length: 175 bp

>AT174424 NZ_CP062342:c19169-18995 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGACTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin