Detailed information of TA system TA174418

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2617738..2618000
• Replicon: chromosome
• Accession: NZ_CP062340
• Organism: Staphylococcus aureus strain NAS_AN_275

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: IF742_RS12950
• Protein ID: WP_001802298.1
• Coordinates: 2617738..2617842 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2617837..2618000 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IF742_RS12935	2614539..2615321	+	783	WP_000908189.1	ABC transporter ATP-binding protein	-
IF742_RS12940	2615389..2616242	+	854	Protein_2517	HAD family hydrolase	-
IF742_RS12945	2616900..2617058	-	159	WP_001792784.1	hypothetical protein	-
IF742_RS12950	2617738..2617842	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2617837..2618000	-	164	-	-	Antitoxin
IF742_RS12960	2618284..2619375	-	1092	WP_000495681.1	hypothetical protein	-
IF742_RS12965	2619641..2620621	-	981	WP_000019743.1	CDF family zinc efflux transporter CzrB	-
IF742_RS12970	2620623..2620943	-	321	WP_000003755.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
IF742_RS12975	2621095..2621760	+	666	WP_001024095.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T174418 WP_001802298.1 NZ_CP062340:2617738-2617842 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T174418 NZ_CP081008:1726071-1726178 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 164 bp

>AT174418 NZ_CP062340:c2618000-2617837 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin