Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2617738..2618000 Replicon chromosome
Accession NZ_CP062340
Organism Staphylococcus aureus strain NAS_AN_275

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag IF742_RS12950 Protein ID WP_001802298.1
Coordinates 2617738..2617842 (+) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2617837..2618000 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF742_RS12935 2614539..2615321 + 783 WP_000908189.1 ABC transporter ATP-binding protein -
IF742_RS12940 2615389..2616242 + 854 Protein_2517 HAD family hydrolase -
IF742_RS12945 2616900..2617058 - 159 WP_001792784.1 hypothetical protein -
IF742_RS12950 2617738..2617842 + 105 WP_001802298.1 hypothetical protein Toxin
- 2617837..2618000 - 164 - - Antitoxin
IF742_RS12960 2618284..2619375 - 1092 WP_000495681.1 hypothetical protein -
IF742_RS12965 2619641..2620621 - 981 WP_000019743.1 CDF family zinc efflux transporter CzrB -
IF742_RS12970 2620623..2620943 - 321 WP_000003755.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
IF742_RS12975 2621095..2621760 + 666 WP_001024095.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T174418 WP_001802298.1 NZ_CP062340:2617738-2617842 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T174418 NZ_CP081008:1726071-1726178 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 164 bp

>AT174418 NZ_CP062340:c2618000-2617837 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References