Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2308060..2308583 Replicon chromosome
Accession NZ_CP062340
Organism Staphylococcus aureus strain NAS_AN_275

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag IF742_RS11365 Protein ID WP_000074046.1
Coordinates 2308317..2308583 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2K4AGF2
Locus tag IF742_RS11360 Protein ID WP_000587615.1
Coordinates 2308060..2308317 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF742_RS11340 (2303155) 2303155..2304348 + 1194 WP_000675403.1 MFS transporter -
IF742_RS11345 (2304572) 2304572..2305321 - 750 WP_000019956.1 CPBP family lipoprotein N-acylation protein LnsB -
IF742_RS11350 (2305511) 2305511..2307088 + 1578 WP_000143490.1 FMN-binding glutamate synthase family protein -
IF742_RS11355 (2307238) 2307238..2307702 - 465 WP_000736689.1 DUF1307 domain-containing protein -
IF742_RS11360 (2308060) 2308060..2308317 + 258 WP_000587615.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
IF742_RS11365 (2308317) 2308317..2308583 + 267 WP_000074046.1 Txe/YoeB family addiction module toxin Toxin
IF742_RS11370 (2308896) 2308896..2309972 + 1077 WP_001076667.1 M42 family metallopeptidase -
IF742_RS11375 (2310220) 2310220..2310882 + 663 WP_000923528.1 ATP-binding cassette domain-containing protein -
IF742_RS11380 (2310875) 2310875..2311648 + 774 WP_000072148.1 iron export ABC transporter permease subunit FetB -
IF742_RS11385 (2312000) 2312000..2313184 + 1185 WP_000115415.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10658.27 Da        Isoelectric Point: 10.1384

>T174414 WP_000074046.1 NZ_CP062340:2308317-2308583 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKPFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T174414 NZ_CP081007:c4646383-4646276 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9746.68 Da        Isoelectric Point: 4.1111

>AT174414 WP_000587615.1 NZ_CP062340:2308060-2308317 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLDDWKSIQETIYLESTGTMDKVRDREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT174414 NZ_CP081007:4646431-4646498 [Escherichia coli]
GTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2K4AGF2

References