Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 947492..947906 | Replicon | chromosome |
| Accession | NZ_CP062340 | ||
| Organism | Staphylococcus aureus strain NAS_AN_275 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | IF742_RS04735 | Protein ID | WP_217799748.1 |
| Coordinates | 947655..947906 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IF742_RS04730 | Protein ID | WP_000028424.1 |
| Coordinates | 947492..947665 (-) | Length | 58 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IF742_RS04685 (943661) | 943661..944938 | - | 1278 | WP_000169946.1 | PBSX family phage terminase large subunit | - |
| IF742_RS04690 (944925) | 944925..945365 | - | 441 | WP_001003272.1 | terminase small subunit | - |
| IF742_RS04695 (945552) | 945552..945971 | - | 420 | WP_000058632.1 | transcriptional regulator | - |
| IF742_RS04700 (945986) | 945986..946132 | - | 147 | WP_000990006.1 | hypothetical protein | - |
| IF742_RS04705 (946133) | 946133..946306 | - | 174 | WP_061823636.1 | transcriptional activator RinB | - |
| IF742_RS04710 (946303) | 946303..946509 | - | 207 | WP_000195791.1 | DUF1381 domain-containing protein | - |
| IF742_RS04715 (946506) | 946506..946751 | - | 246 | WP_000120373.1 | hypothetical protein | - |
| IF742_RS04720 (946788) | 946788..947315 | - | 528 | WP_070014292.1 | dUTPase | - |
| IF742_RS04725 (947330) | 947330..947491 | - | 162 | WP_000889682.1 | hypothetical protein | - |
| IF742_RS04730 (947492) | 947492..947665 | - | 174 | WP_000028424.1 | hypothetical protein | Antitoxin |
| IF742_RS04735 (947655) | 947655..947906 | - | 252 | WP_217799748.1 | DUF1024 family protein | Toxin |
| IF742_RS04740 (947899) | 947899..948207 | - | 309 | WP_000144708.1 | hypothetical protein | - |
| IF742_RS04745 (948204) | 948204..948551 | - | 348 | WP_000979209.1 | YopX family protein | - |
| IF742_RS04750 (948548) | 948548..948949 | - | 402 | WP_000695759.1 | hypothetical protein | - |
| IF742_RS04755 (948952) | 948952..949158 | - | 207 | WP_000693987.1 | hypothetical protein | - |
| IF742_RS04760 (949172) | 949172..949420 | - | 249 | WP_060474161.1 | SAV1978 family virulence-associated passenger protein | - |
| IF742_RS04765 (949420) | 949420..949674 | - | 255 | WP_000022736.1 | DUF3310 domain-containing protein | - |
| IF742_RS04770 (949674) | 949674..950036 | - | 363 | WP_000536051.1 | SA1788 family PVL leukocidin-associated protein | - |
| IF742_RS04775 (950037) | 950037..950222 | - | 186 | WP_001187252.1 | DUF3113 family protein | - |
| IF742_RS04780 (950227) | 950227..950631 | - | 405 | WP_015973976.1 | DUF1064 domain-containing protein | - |
| IF742_RS04785 (950642) | 950642..950863 | - | 222 | WP_001123688.1 | DUF3269 family protein | - |
| IF742_RS04790 (950877) | 950877..951035 | - | 159 | WP_000628834.1 | hypothetical protein | - |
| IF742_RS04795 (951032) | 951032..951817 | - | 786 | WP_000443353.1 | ATP-binding protein | - |
| IF742_RS04800 (951830) | 951830..952591 | - | 762 | WP_000132053.1 | conserved phage C-terminal domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 918185..967290 | 49105 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9405.36 Da Isoelectric Point: 3.8928
>T174412 WP_217799748.1 NZ_CP062340:c947906-947655 [Staphylococcus aureus]
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
MNNREKIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY
Download Length: 252 bp
>T174412 NZ_CP081007:c4275857-4275606 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Antitoxin
Download Length: 58 a.a. Molecular weight: 6468.29 Da Isoelectric Point: 4.2484
>AT174412 WP_000028424.1 NZ_CP062340:c947665-947492 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE
Download Length: 174 bp
>AT174412 NZ_CP081007:c4275609-4275355 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|